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NEJM:无创消融放射治疗用于治疗高危难治性室性心动过速

2017-12-14 zhangfan MedSci原创

研究认为,对于高危难治性室性心动过速患者,无创性心脏电生理指导消融放射治疗可明显减少患者疾病负担

近日研究人员结合心电图成像以及立体定向消融放射治疗(SBRT)技术,考察了电生理引导无创心脏射频消融术在治疗致室性心动过速中的应用前景。

研究人员通过植入式心脏复律除颤器将室性心动过速患者的解剖学影像与无创心电图诊断相结合,针对心律失常性瘢痕区进行SBRT刺激,患者每次接受25Gy的辐射治疗,通过室性心动过速计数评估疗效,通过胸部及心脏影像评估治疗的安全性。

2015年4-11月,5名高危难治性室性心动过速患者参与研究,平均无创消融时间为14分。在治疗前3个月,患者室性心动过速发作6577次;治疗6周时,患者室性心动过速发作减少为680次;之后的46个患者随访月中,总计发生了4次室性心动过速发作,较基线下降了99.9%。所有5名患者室性心动过速发作次数均显著下降,左室平均射血分数降低。治疗3个月后,邻近肺表现出轻度炎症改变,1年后缓解。

研究认为,对于高危难治性室性心动过速患者,无创性心脏电生理指导消融放射治疗可明显减少患者疾病负担。

原始出处:

Phillip S. Cuculich et al. Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia N Engl J Med. December 14 2017.

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