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Cell Metab:有规律的饮食习惯或更有益于人体健康

2012-05-24 T.Shen 生物谷

近年来,对于人类来说,减肥迫在眉睫,研究者通过在小鼠中进行研究发现,相比每天都在不间断摄食的小鼠而言(尽管这些小鼠消耗了更多的脂肪),每隔8小时正常摄食的小鼠表现得健康一些。 近日,来自索尔克研究所的研究者进行了一项肥胖和饮食时间相关性的研究;近年来随着人们对食物的不同选择使得人们的健康度越来越低,早餐可能包括健康的水果和一些谷物,但是午夜的小吃却很有可能是高脂肪的冰激凌或高热量的酒精,此外,研

近年来,对于人类来说,减肥迫在眉睫,研究者通过在小鼠中进行研究发现,相比每天都在不间断摄食的小鼠而言(尽管这些小鼠消耗了更多的脂肪),每隔8小时正常摄食的小鼠表现得健康一些。

近日,来自索尔克研究所的研究者进行了一项肥胖和饮食时间相关性的研究;近年来随着人们对食物的不同选择使得人们的健康度越来越低,早餐可能包括健康的水果和一些谷物,但是午夜的小吃却很有可能是高脂肪的冰激凌或高热量的酒精,此外,研究者还揭示了,人类的生物钟和自身的代谢越来越相关,如果破坏了自身的生物钟会引起体重增加甚至肥胖。

研究者Panda和同事以高脂肪食物喂食了两组小鼠,一组可以在任何想吃的时候进行摄食(每天无限制摄食),然而另一组每隔8小时喂食一次,两组小鼠每天消耗的卡路里是一样的,而且两组小鼠都是在一样的情况下喂食健康的食物。

肥胖人的生物钟(Image: Paul Mansfield Photography/Getty Images)

三个月后,每天都在不断摄食的一组小鼠平均体重相比另外一组增加了28%,而且通过测定其血糖水平,已经达到了糖尿病的标准,而且这组小鼠患有不同程度的肝损伤;然而每隔8小时喂食的一组小鼠保持着健康的水平,并没有任何糖尿病风险,而且其保持着健康饮食的水平。

Panda推测,缩短喂食周期将会延长小鼠代谢系统的时间,而且通过营养物质的不断摄入可以完成代谢不间断的功能。目前研究者已经开始征集志愿者进行相关人体研究了。相关研究成果刊登在了近日的国际杂志Cell Metabolism上。

(生物谷:T.Shen编译)

doi:10.1016/j.cmet.2012.04.019
PMC:
PMID:

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

Megumi Hatori1, 4, Christopher Vollmers1, 4, Amir Zarrinpar1, 2, 4, Luciano DiTacchio1, 4, Eric A. Bushong3, Shubhroz Gill1, Mathias Leblanc1, Amandine Chaix1, Matthew Joens1, James A.J. Fitzpatrick1, Mark H. Ellisman3, Satchidananda Panda1, ,

While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.

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    2013-01-20 guojianrong
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    2012-08-02 一闲
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    2012-10-27 维他命

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PLoS Compu Biol:研究者利用谷歌算法来寻找肿瘤生物标记物

在谷歌(Google)搜索引擎中键入搜索关键词就可以用来查询癌症病人的蛋白质和其病程进展的相关性。近日,来自德国德累斯顿理工大学的研究者运用了一种修饰过的Google网页算法对遗传相关的胰腺癌进展的2000个蛋白进行评级,相关研究成果刊登在了近日的国际杂志PLoS Computational Biology上,文章中,研究者找到了7个蛋白质,可以帮助预测肿瘤患者的病程进展,同时也给临床上是否给患者

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