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World Allergy Organ J:哮喘成年人中鼻高反应性的患病率和激发因子研究

2020-07-23 AlexYang MedSci原创

鼻高反应性(NHR)是各种鼻炎亚型的一种常见特征,是鼻炎的一种新的表型。据报道,三分之二的鼻炎患者忽略了特应性反应。目前,关于哮喘患者的NHR患病率数据以及激发因子数据仍旧缺乏。

鼻高反应性(NHR)是各种鼻炎亚型的一种常见特征,是鼻炎的一种新的表型。据报道,三分之二的鼻炎患者忽略了特应性反应。目前,关于哮喘患者的NHR患病率数据以及激发因子数据仍旧缺乏。

在勒芬,研究人员通过邮政调查问卷的方式收集数据,190名哮喘患者中有114名患者完成了调查问卷。在墨西哥城和布拉索夫,分别有97/110和80/100名哮喘患者完成了调查问卷,研究还包括了勒芬的53名无哮喘志愿者。研究发现,69%的哮喘患者具有NHR,32%的患者具有不少于4种的NHR激发因子。激发因子主要包括温度和湿度变化、抽烟和强烈的气味。其中过敏性哮喘患者的NHR要比非过敏性哮喘患者的患病率更高(73% vs. 53% p<0.01)。NHR的患病率与哮喘严重度有关,从63%(VAS≤3)到81%(VAS≥7)。BHR在NHR患者中的频率要比非NHR更高(89% vs. 53%, p<0.0001)。

最后,研究人员指出,NHR是上呼吸道的一种临床症状,影响着不少于三分之二的哮喘患者,且与哮喘严重度相关。在哮喘患者中靶向NHR总是被忽略,因此,应该加强对NHR的关注从而获得更好的症状控制效果。

原始出处:

Jef Feijen , Sven F Seys , Brecht Steelant et al. Prevalence and triggers of self-reported nasal hyperreactivity in adults with asthma. World Allergy Organ J. Jul 1 2020.

 

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    2020-08-08 ms3000000989158915

    已阅

    0

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Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-25 膀胱癌
  5. [GetPortalCommentsPageByObjectIdResponse(id=2022847, encodeId=c957202284e6c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Apr 28 21:32:48 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806991, encodeId=6f5e8069912b, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06ff5402430, createdName=ms3000000989158915, createdTime=Sat Aug 08 20:01:30 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250701, encodeId=002a1250e0161, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329399, encodeId=c5c51329399d9, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804168, encodeId=08cb804168ce, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75402398, createdName=ms5000001542627283, createdTime=Thu Jul 23 18:59:45 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804167, encodeId=cb9b80416e57, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b945401957, createdName=ms1000001203941975, createdTime=Thu Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 ms5000001542627283

    阅读

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2022847, encodeId=c957202284e6c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Apr 28 21:32:48 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806991, encodeId=6f5e8069912b, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06ff5402430, createdName=ms3000000989158915, createdTime=Sat Aug 08 20:01:30 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250701, encodeId=002a1250e0161, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329399, encodeId=c5c51329399d9, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804168, encodeId=08cb804168ce, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75402398, createdName=ms5000001542627283, createdTime=Thu Jul 23 18:59:45 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804167, encodeId=cb9b80416e57, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b945401957, createdName=ms1000001203941975, createdTime=Thu Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 ms1000001203941975

    已阅

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2022847, encodeId=c957202284e6c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Apr 28 21:32:48 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806991, encodeId=6f5e8069912b, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06ff5402430, createdName=ms3000000989158915, createdTime=Sat Aug 08 20:01:30 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250701, encodeId=002a1250e0161, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329399, encodeId=c5c51329399d9, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804168, encodeId=08cb804168ce, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75402398, createdName=ms5000001542627283, createdTime=Thu Jul 23 18:59:45 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804167, encodeId=cb9b80416e57, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b945401957, createdName=ms1000001203941975, createdTime=Thu Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 13f64d75m77暂无昵称

    阅读

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2022847, encodeId=c957202284e6c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Apr 28 21:32:48 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806991, encodeId=6f5e8069912b, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06ff5402430, createdName=ms3000000989158915, createdTime=Sat Aug 08 20:01:30 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250701, encodeId=002a1250e0161, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329399, encodeId=c5c51329399d9, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804168, encodeId=08cb804168ce, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75402398, createdName=ms5000001542627283, createdTime=Thu Jul 23 18:59:45 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804167, encodeId=cb9b80416e57, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b945401957, createdName=ms1000001203941975, createdTime=Thu Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 街角对面的大米店

    阅读

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2022847, encodeId=c957202284e6c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Apr 28 21:32:48 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806991, encodeId=6f5e8069912b, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06ff5402430, createdName=ms3000000989158915, createdTime=Sat Aug 08 20:01:30 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250701, encodeId=002a1250e0161, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329399, encodeId=c5c51329399d9, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804168, encodeId=08cb804168ce, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75402398, createdName=ms5000001542627283, createdTime=Thu Jul 23 18:59:45 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804167, encodeId=cb9b80416e57, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b945401957, createdName=ms1000001203941975, createdTime=Thu Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 heli0118

    #哮喘#鼻高反应性于呼吸道高反应性,应该有相关性。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2022847, encodeId=c957202284e6c, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Wed Apr 28 21:32:48 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806991, encodeId=6f5e8069912b, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06ff5402430, createdName=ms3000000989158915, createdTime=Sat Aug 08 20:01:30 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250701, encodeId=002a1250e0161, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52988, encryptionId=7d6f52988e1, topicName=患病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329399, encodeId=c5c51329399d9, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat Jul 25 04:32:48 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804168, encodeId=08cb804168ce, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fef75402398, createdName=ms5000001542627283, createdTime=Thu Jul 23 18:59:45 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804167, encodeId=cb9b80416e57, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b945401957, createdName=ms1000001203941975, createdTime=Thu Jul 23 18:59:00 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804163, encodeId=805c8041638a, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a37d4313484, createdName=13f64d75m77暂无昵称, createdTime=Thu Jul 23 18:06:57 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804160, encodeId=99ed804160c1, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoeEYicaoSDvLzl6Rtwiblf207icXFJnruGZBAHpLm6KiaqRbm38nWkZNpaLPGsVhRnR5WjJUOnqBCSyg/132, createdBy=b1702138478, createdName=街角对面的大米店, createdTime=Thu Jul 23 17:55:47 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804137, encodeId=a0de80413e8a, content=<a href='/topic/show?id=052d399242a' target=_blank style='color:#2F92EE;'>#哮喘#</a>鼻高反应性于呼吸道高反应性,应该有相关性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39924, encryptionId=052d399242a, topicName=哮喘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Jul 23 16:10:37 CST 2020, time=2020-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804136, encodeId=dadb804136ec, content=阅读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210521/32b8d3a7255b4e1e97e3d0ae8cf16e8d/a96e9c51e902409eaacab5e9fcc28c1e.jpg, createdBy=15f45402018, createdName=ms1000000554757526, createdTime=Thu Jul 23 16:09:48 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 ms1000000554757526

    阅读

    0

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