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Gastroenterology:炎症性肠病患者肠道菌群变化研究

2020-03-17 MedSci原创 MedSci原创

研究证实炎症性肠病患者肠道部分细菌丰度存在差异

改变肠道微生物群是一种治疗炎症性肠病(IBD)的潜在方法,近日研究人员开展系统回顾和荟萃分析考察特定微生物和IBD之间的联系。

研究人员收集截至2018年4月的相关资料,涉及比较IBD患者(成人或儿童)与健康人(对照组)之间的肠道微生物群(来自粪便、结肠或回肠组织样本)差异的研究均纳入本次荟萃分析。

总计45篇文章,48项研究纳入本次荟萃分析,大多数患者为克罗恩病(CD)或溃疡性结肠炎(UC)成年人。与对照组相比, CD患者Christensenellae、Coriobacteriae以及Faecalibacterium prausnitzii菌群的数量减少,而放线菌、Veillonella和大肠杆菌的数量增加。UC患者Eubacterium rectale和Akkermansia数量减少,大肠杆菌含量增加。与对照组相比,IBD患者的微生物多样性降低或无差异。不到50%的研究表明病例和对照的性别和年龄具有可比性。

研究证实炎症性肠病患者肠道部分细菌丰度存在差异。

原始出处:

Rapat Pittayanon et al. Differences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review. Gastroenterology. March 2020.

 

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    2020-06-22 许安
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血清二肽基肽酶4(DPP-4)作为炎症性肠病(IBD)的生物标记物目前引起了很多学者的兴趣,因为该蛋白酶可以使参与炎症级联反应的几种肽失活。因此,本项研究将对此进行相关研究。

BMC Gastroenterology:白细胞介素10信号不足与早期炎症性肠病肠造口并发症相关

白介素10(IL10)信号通路缺乏会导致严重的非常早期的炎症性肠病(VEOIBD),并且肠造口术通常是不可避免的。本研究旨在炎症性肠病患者肠造口术特征,术后并发症和相关危险因素。

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