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第61届ASH：Mustang Bio宣布MB-107和MB-106慢病毒基因疗法的全新数据

2019-11-07 Allan MedSci原创

MB-107MB-106慢病毒基因疗法
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Mustang Bio是一家临床阶段的生物制药公司，致力于使用先进的细胞和基因疗法治疗血液学癌症。在第61届美国血液病学会（ASH）年会上，Mustang Bio的MB-107和MB-106慢病毒基因疗法治疗X连锁严重综合免疫缺陷症（XSCID）的I/II期临床数据将被披露。ASH将于2019年12月7日至10日在佛罗里达州奥兰多举行。

Mustang Bio是一家临床阶段的生物制药公司，致力于使用先进的细胞和基因疗法治疗血液学癌症。在第61届美国血液病学会（ASH）年会上，Mustang Bio的MB-107和MB-106慢病毒基因疗法治疗X连锁严重综合免疫缺陷症（XSCID）的I/II期临床数据将被披露。ASH将于2019年12月7日至10日在佛罗里达州奥兰多举行。

X连锁重症联合免疫缺陷症（X-SCID）是由IL2RG中半合子的致病性变异引起的细胞与体液联合免疫缺陷综合征。在典型的X-SCID中，缺乏IL2RG功能导致几乎完全缺乏T和自然杀伤（NK）淋巴细胞和非功能性B淋巴细胞。除非通过骨髓移植或基因治疗实现免疫系统的重建，否则X-SCID在生命的头两年几乎全都是致命的。


原始出处：

http://www.firstwordpharma.com/node/1679094#axzz64Xy4dOaT

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    2020-06-09 jingyanzhu715_39486101

    #MB-107#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2029734, encodeId=897e2029e344b, content=<a href='/topic/show?id=a58911344f1' target=_blank style='color:#2F92EE;'>#MB-107#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11344, encryptionId=a58911344f1, topicName=MB-107)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3e72500135, createdName=jingyanzhu715_39486101, createdTime=Tue Jun 09 13:37:00 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803696, encodeId=7902180369694, content=<a href='/topic/show?id=fe00e5728a9' target=_blank style='color:#2F92EE;'>#第61届ASH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75728, encryptionId=fe00e5728a9, topicName=第61届ASH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Tue Jul 28 06:37:00 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045234, encodeId=12a1204523455, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Mon Dec 23 23:37:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918920, encodeId=09f9191892075, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 14 19:37:00 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301282, encodeId=a5b51301282c3, content=<a href='/topic/show?id=38e32852fe' target=_blank style='color:#2F92EE;'>#ASH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2852, encryptionId=38e32852fe, topicName=ASH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=39a0295, createdName=kksonne, createdTime=Fri Nov 08 23:37:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401551, encodeId=5659140155183, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Nov 08 23:37:00 CST 2019, time=2019-11-08, status=1, ipAttribution=)]
    2020-07-28 ms7421025882867189

    #第61届ASH#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2029734, encodeId=897e2029e344b, content=<a href='/topic/show?id=a58911344f1' target=_blank style='color:#2F92EE;'>#MB-107#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11344, encryptionId=a58911344f1, topicName=MB-107)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3e72500135, createdName=jingyanzhu715_39486101, createdTime=Tue Jun 09 13:37:00 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803696, encodeId=7902180369694, content=<a href='/topic/show?id=fe00e5728a9' target=_blank style='color:#2F92EE;'>#第61届ASH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75728, encryptionId=fe00e5728a9, topicName=第61届ASH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Tue Jul 28 06:37:00 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045234, encodeId=12a1204523455, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Mon Dec 23 23:37:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918920, encodeId=09f9191892075, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 14 19:37:00 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301282, encodeId=a5b51301282c3, content=<a href='/topic/show?id=38e32852fe' target=_blank style='color:#2F92EE;'>#ASH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2852, encryptionId=38e32852fe, topicName=ASH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=39a0295, createdName=kksonne, createdTime=Fri Nov 08 23:37:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401551, encodeId=5659140155183, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Nov 08 23:37:00 CST 2019, time=2019-11-08, status=1, ipAttribution=)]
    2019-12-23 lishiwen

    #慢病毒基因疗法#

    0

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    2020-07-14 sunylz

    #Bio#

    0

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    2019-11-08 kksonne

    #ASH#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2029734, encodeId=897e2029e344b, content=<a href='/topic/show?id=a58911344f1' target=_blank style='color:#2F92EE;'>#MB-107#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11344, encryptionId=a58911344f1, topicName=MB-107)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3e72500135, createdName=jingyanzhu715_39486101, createdTime=Tue Jun 09 13:37:00 CST 2020, time=2020-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1803696, encodeId=7902180369694, content=<a href='/topic/show?id=fe00e5728a9' target=_blank style='color:#2F92EE;'>#第61届ASH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75728, encryptionId=fe00e5728a9, topicName=第61届ASH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Tue Jul 28 06:37:00 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2045234, encodeId=12a1204523455, content=<a href='/topic/show?id=273b53e546c' target=_blank style='color:#2F92EE;'>#慢病毒基因疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53754, encryptionId=273b53e546c, topicName=慢病毒基因疗法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c0050, createdName=lishiwen, createdTime=Mon Dec 23 23:37:00 CST 2019, time=2019-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918920, encodeId=09f9191892075, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Tue Jul 14 19:37:00 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301282, encodeId=a5b51301282c3, content=<a href='/topic/show?id=38e32852fe' target=_blank style='color:#2F92EE;'>#ASH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2852, encryptionId=38e32852fe, topicName=ASH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=39a0295, createdName=kksonne, createdTime=Fri Nov 08 23:37:00 CST 2019, time=2019-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401551, encodeId=5659140155183, content=<a href='/topic/show?id=b9c853e521b' target=_blank style='color:#2F92EE;'>#慢病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53752, encryptionId=b9c853e521b, topicName=慢病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9bf2348479, createdName=ymljack, createdTime=Fri Nov 08 23:37:00 CST 2019, time=2019-11-08, status=1, ipAttribution=)]
    2019-11-08 ymljack

    #慢病毒#

    0

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