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Hypertension:主动脉-肱动脉硬化梯度与心血管风险有啥关系?

2017-04-11 xing.T MedSci原创

该研究结果表明,PWV比的预后意义可能会根据基础CVD风险而有所不同,并且在评估社区人群血管硬化中应继续使用CFPWV标准。

最近的一项研究报道主动脉肱动脉硬化梯度,其定义为颈-桡动脉脉搏波速度/颈-股动脉脉搏波速度(PWV比),可以比颈-股动脉脉搏波速度(CFPWV)能更好地预测透析患者的全因死亡率。然而,PWV比对社区人群血管疾病(CVD)的预后意义尚不清楚。近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员评估了Framingham心脏研究中无明显心血管疾病的2114名参与者(60±10岁;女性为56%)PWV比的相关和预测价值。

平均PWV比从小于40岁参与者的1.36±0.19下降到那些超过80岁参与者的0.73±0.21。在多元线性回归分析中,年龄较大、男性、体重指数较大、糖尿病、高密度脂蛋白胆固醇较低、平均动脉压较高和心率更高与较低的PWV比相关(所有P<0.001)。

在中位随访12.6年期间,发生了248次首发CVD事件。在调整了标准心血管危险因素的Cox回归模型中,CFPWV (风险比为1.33;95%可信区间为1.10-1.61)和PWV比(风险比为1.32;95%可信区间为1.09-1.59)每变化一个标准差具有类似的CVD风险。包括传统的CVD危险因素,再加上CFPWV或PWV比的模型得到了相同C统计值(C=0.783)。虽然在透析患者中PWV比已报道比CFPWV提供更多的预测价值,但是研究人员不能在社区为基础的样本中重复这些结果。

该研究结果表明,PWV比的预后意义可能会根据基础CVD风险而有所不同,并且在评估社区人群血管硬化中应继续使用CFPWV标准。

原始出处:


Teemu J. Niiranen, et al. Aortic-Brachial Arterial Stiffness Gradient and Cardiovascular Risk in the Community The Framingham Heart Study.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.116.08917

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    2017-06-03 feather89
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    2017-04-14 laymankey

    感谢分享一下!

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=186711, encodeId=0c83186e11ac, content=真是个好软件, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2mWuYFQXy09AK9oNRmQryAhfR8hOnpwuyxHLIv9YRRJLFMP9JEnJYCMRbPfPcib9vmUTNcOP9p5Lg/0, createdBy=63de2048613, createdName=纽扣, createdTime=Tue Apr 11 18:42:39 CST 2017, time=2017-04-11, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1726353, encodeId=d9591e26353ea, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Jun 03 00:10:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038624, encodeId=5804203862441, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 04 17:10:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082404, encodeId=871b20824047e, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Jul 19 09:10:00 CST 2017, time=2017-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808517, encodeId=f190180851eca, content=<a href='/topic/show?id=cc11819802a' target=_blank style='color:#2F92EE;'>#肱动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81980, encryptionId=cc11819802a, topicName=肱动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Tue Jul 18 00:10:00 CST 2017, time=2017-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187402, encodeId=e0eb18e40261, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Fri Apr 14 14:55:40 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415124, encodeId=2a5c1415124a2, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Apr 13 09:10:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501148, encodeId=4f4c1501148fe, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Apr 13 09:10:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186723, encodeId=7134186e2352, content=感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 11 19:48:54 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186712, encodeId=5601186e12da, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Tue Apr 11 18:52:56 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186711, encodeId=0c83186e11ac, content=真是个好软件, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2mWuYFQXy09AK9oNRmQryAhfR8hOnpwuyxHLIv9YRRJLFMP9JEnJYCMRbPfPcib9vmUTNcOP9p5Lg/0, createdBy=63de2048613, createdName=纽扣, createdTime=Tue Apr 11 18:42:39 CST 2017, time=2017-04-11, status=1, ipAttribution=)]
    2017-04-11 ylzr123

    感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1726353, encodeId=d9591e26353ea, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Jun 03 00:10:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038624, encodeId=5804203862441, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 04 17:10:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082404, encodeId=871b20824047e, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Jul 19 09:10:00 CST 2017, time=2017-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808517, encodeId=f190180851eca, content=<a href='/topic/show?id=cc11819802a' target=_blank style='color:#2F92EE;'>#肱动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81980, encryptionId=cc11819802a, topicName=肱动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Tue Jul 18 00:10:00 CST 2017, time=2017-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187402, encodeId=e0eb18e40261, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Fri Apr 14 14:55:40 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415124, encodeId=2a5c1415124a2, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Apr 13 09:10:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501148, encodeId=4f4c1501148fe, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Apr 13 09:10:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186723, encodeId=7134186e2352, content=感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 11 19:48:54 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186712, encodeId=5601186e12da, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Tue Apr 11 18:52:56 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186711, encodeId=0c83186e11ac, content=真是个好软件, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2mWuYFQXy09AK9oNRmQryAhfR8hOnpwuyxHLIv9YRRJLFMP9JEnJYCMRbPfPcib9vmUTNcOP9p5Lg/0, createdBy=63de2048613, createdName=纽扣, createdTime=Tue Apr 11 18:42:39 CST 2017, time=2017-04-11, status=1, ipAttribution=)]
    2017-04-11 komasun

    学习了谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1726353, encodeId=d9591e26353ea, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Jun 03 00:10:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038624, encodeId=5804203862441, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Dec 04 17:10:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082404, encodeId=871b20824047e, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Jul 19 09:10:00 CST 2017, time=2017-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808517, encodeId=f190180851eca, content=<a href='/topic/show?id=cc11819802a' target=_blank style='color:#2F92EE;'>#肱动脉#</a>, beContent=null, objectType=article, channel=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Apr 13 09:10:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501148, encodeId=4f4c1501148fe, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Thu Apr 13 09:10:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186723, encodeId=7134186e2352, content=感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 11 19:48:54 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186712, encodeId=5601186e12da, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib0kbzef1jKfxVxKKxoGdVMdMe54JuaABgJlOdkfVdUkxEReXZyZ0PMHhxlzMkiciaPAp2gJsoIbGKtA/0, createdBy=a2d51960177, createdName=komasun, createdTime=Tue Apr 11 18:52:56 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186711, encodeId=0c83186e11ac, content=真是个好软件, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2mWuYFQXy09AK9oNRmQryAhfR8hOnpwuyxHLIv9YRRJLFMP9JEnJYCMRbPfPcib9vmUTNcOP9p5Lg/0, createdBy=63de2048613, createdName=纽扣, createdTime=Tue Apr 11 18:42:39 CST 2017, time=2017-04-11, status=1, ipAttribution=)]
    2017-04-11 纽扣

    真是个好软件

    0

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