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Sci Rep:较低的平均血小板体积可以预测肾细胞癌不良预后

2017-07-29 AlexYang MedSci原创

之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识。最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。研

之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识

最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。

研究发现,在306名RCC病人中,低MPV水平在61名病人中检测到(19.9%)。减少的MPV与组织学类型、T分期、加州大学洛杉矶分校综合评分系统(UISS)分类、梅奥临床分期、尺寸、等级和坏死得分(SSIGN)分类相关(P<0.05)。另外,具有减少MPV的病人和具有正常MPV病人相比,生存时间更短(P<0.001)。Cox回归分析表明,减少的MPV是总生存的一个独立预后因子(hazard ratio, 1.758; 95% confidence interval [CI], 1.083-2.855, P=0.023)。更多的是,TNM阶段、UISS和SSIGN预后模型的预后准确性因MPV参数的增加而得到改善。总之,研究人员指出,减少的MPV在RCC中是不良临床结果的一个独立预测因子。

原始出处:

Zhi-yuan Yun, Xin Zhang, Yan-song Liu et al. Lower mean platelet volume predicts poor prognosis in renal cell carcinoma. Sci Rep. 27 July 2017.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1978529, encodeId=f82f19e852967, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun May 27 20:41:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228764, encodeId=986c228e640f, content=谢谢分享,很不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Aug 01 09:42:31 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336352, encodeId=45801336352b5, content=<a href='/topic/show?id=071820530c5' target=_blank style='color:#2F92EE;'>#不良预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20530, encryptionId=071820530c5, topicName=不良预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Mon Jul 31 04:41:00 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227769, encodeId=f01e22e76919, content=zx谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 29 19:19:18 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227682, encodeId=7e8422e68294, content=最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:39 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227681, encodeId=713222e681e4, content=之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:31 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-08-01 明天会更好!

    谢谢分享,很不错。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1978529, encodeId=f82f19e852967, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun May 27 20:41:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228764, encodeId=986c228e640f, content=谢谢分享,很不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Aug 01 09:42:31 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336352, encodeId=45801336352b5, content=<a href='/topic/show?id=071820530c5' target=_blank style='color:#2F92EE;'>#不良预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20530, encryptionId=071820530c5, topicName=不良预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Mon Jul 31 04:41:00 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227769, encodeId=f01e22e76919, content=zx谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 29 19:19:18 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227682, encodeId=7e8422e68294, content=最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:39 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227681, encodeId=713222e681e4, content=之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:31 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1978529, encodeId=f82f19e852967, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun May 27 20:41:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228764, encodeId=986c228e640f, content=谢谢分享,很不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Aug 01 09:42:31 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336352, encodeId=45801336352b5, content=<a href='/topic/show?id=071820530c5' target=_blank style='color:#2F92EE;'>#不良预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20530, encryptionId=071820530c5, topicName=不良预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Mon Jul 31 04:41:00 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227769, encodeId=f01e22e76919, content=zx谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 29 19:19:18 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227682, encodeId=7e8422e68294, content=最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:39 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227681, encodeId=713222e681e4, content=之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:31 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 清风拂面

    zx谢谢分享,学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1978529, encodeId=f82f19e852967, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Sun May 27 20:41:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228764, encodeId=986c228e640f, content=谢谢分享,很不错。, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Aug 01 09:42:31 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336352, encodeId=45801336352b5, content=<a href='/topic/show?id=071820530c5' target=_blank style='color:#2F92EE;'>#不良预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20530, encryptionId=071820530c5, topicName=不良预后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c97a2500111, createdName=thinkibmz_44722594, createdTime=Mon Jul 31 04:41:00 CST 2017, time=2017-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227769, encodeId=f01e22e76919, content=zx谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 29 19:19:18 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227682, encodeId=7e8422e68294, content=最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:39 CST 2017, time=2017-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=227681, encodeId=713222e681e4, content=之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3wrgsNyr5lh6N2MY5xSnbvo4g5sRlc3MZoDdWpMeSdozUCPNhA96wndwQe3X5Z5oYMNxVUdOib63nw/0, createdBy=d8d11998754, createdName=Julie W, createdTime=Sat Jul 29 14:11:31 CST 2017, time=2017-07-29, status=1, ipAttribution=)]
    2017-07-29 Julie W

    最近,有研究人员调查了MPV值作为一个RCC预后因子的可能性。该回顾性的研究招募了在2009年1月到2009年12月的306名连续的RCC病人。研究人员对MPV和临床病理学特性的关系进行了分析,并利用卡普兰-梅尔分析方法和Cox回归评估了MPV的预后影响。

    0

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    2017-07-29 Julie W

    之前的研究发现,改变的的平均血小板体积(MPV)在几种恶性肿瘤中存在。值得注意的是,MPV在肾细胞癌(RCC)中预后评估的价值还没有达成共识。

    0

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