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PLoS One:非酒精性脂肪肝疾病与前列腺癌的发展相关吗?

2018-09-21 AlexYang MedSci原创

越来越多的证据支持前列腺癌(PCa)是一种代谢综合征相关的癌症,但是在非酒精性脂肪肝(NAFLD)和PCa之间的相关性方面还缺乏证据。最近,有研究人员在韩国成年人中调查了是否PCa与NAFLD相关。研究人员利用多变量逻辑回归的方法对数据进行了分析。NALFD是基于脂肪肝指数(FLI)和脂肪肝变性指数(HSI)来定义。研究发现,基于FLI和HIS的NAFLD在10516985名参与者中分别鉴定到了2

越来越多的证据支持前列腺癌(PCa)是一种代谢综合征相关的癌症,但是在非酒精性脂肪肝(NAFLD)和PCa之间的相关性方面还缺乏证据。最近,有研究人员在韩国成年人中调查了是否PCa与NAFLD相关。

研究人员利用多变量逻辑回归的方法对数据进行了分析。NALFD是基于脂肪肝指数(FLI)和脂肪肝变性指数(HSI)来定义。研究发现,基于FLI和HIS的NAFLD在10516985名参与者中分别鉴定到了2002375(19%)名和2629858(25%)名。在调整了其他的混杂因素后,FLI ≥ 60和HSI ≥ 36均与PCa的发展独立相关(风险比(HR)1.09,95%CI:1.06-1.12;HR 1.19, 95% CI: 1.16-1.23)。上述相关性在那些年龄更大(FLI, ≥ 65岁HSI, ≥ 40岁)、不抽烟、酒精消费小于30g每天和无代谢综合正成分的患者中比对应的患者更加明显。通过HIS定义的NAFLD非肥胖个人具有比那些身体质量指数大于25Kg/m2的个人具有更高的发展为PCa的风险。

最后,研究人员指出,通过FLI和HIS定义的NAFLD可能对鉴定高风险发展为PCa的个人,尤其是在那些年龄大的,甚至是不肥胖和没有代谢综合症的个人中尤其适用。另外,研究人员还指出基于超声的发现从而对他们的研究结果进行重复也是必要的。

原始出处:


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  5. [GetPortalCommentsPageByObjectIdResponse(id=1673431, encodeId=220e16e343194, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Tue Mar 12 02:20:00 CST 2019, time=2019-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1926607, encodeId=5904192660efe, content=<a href='/topic/show?id=4d9799e29d7' target=_blank style='color:#2F92EE;'>#非酒精性脂肪肝疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99729, encryptionId=4d9799e29d7, topicName=非酒精性脂肪肝疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Fri Nov 02 03:20:00 CST 2018, time=2018-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676432, encodeId=f67216e6432bc, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Fri Jun 28 23:20:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980487, encodeId=9b05198048e98, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Fri Aug 16 07:20:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1790263, encodeId=71f71e902634a, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Aug 20 11:20:00 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346076, encodeId=19e13460e6a3, content=需要研究一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/24/d9d14db78de202d73276f47d8d8e2596.jpg, createdBy=3b682249905, createdName=盖伦, createdTime=Sat Sep 22 05:58:08 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346057, encodeId=f99934605ec8, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 21 22:35:51 CST 2018, time=2018-09-21, status=1, ipAttribution=)]
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    2018-09-22 盖伦

    需要研究一下

    0

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    2018-09-21 天地飞扬

    了解一下,谢谢分享!

    0

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Clin Cancer Res:前列腺癌荧光指导的手术中,新型前列腺特异性膜抗原靶向近红外成像剂评估

在根治性前列腺切除手术中准确定位和移除所有恶性病变部位不仅能够阻止生化复发(BCR)和可能的副作用,同时也能够改善前列腺癌患者(PCa)的生活期望。荧光指导的手术(FGS)作为一种新的技术,主要利用荧光在显示癌症细胞,并且指导手术医生来及时切除肿瘤。因此,肿瘤特异性近红外(NIR)靶向生物标记的成像剂的开发将能够人们评估阴性肿瘤切缘和受影响的淋巴结。由于PSMA在大于90%的PCa患者群体中均过表

Cancer Lett:TMPRSS2:ERG基因融合表达能够调控骨标记和增强前列腺癌骨转移成骨细胞表型

前列腺癌具有很强的转移到骨组织的倾向性,并且促进成骨细胞病变。TMPRSS2:ERG是前列腺癌中最常见的基因重排,但是是否该基因重排参与前列腺癌骨转移仍旧未知。最近,有研究人员探索了一个转移模型来探究上述问题,并且发现,TMPRSS2:ERG融合基因的异位表达能够增强前列腺癌细胞系诱导成骨细胞病变的能力,具体是铜鼓刺激骨组织形成和抑制溶骨响应。与这些结果的体内结果一致,研究人员阐释了TMPRSS2

J Exp Clin Cancer Res:内皮细胞能够通过增强细胞自噬来促进前列腺癌转

前列腺癌是一种最常见的的恶性肿瘤之一。越来越多的证据表明内皮细胞能够导致前列腺癌的恶化和转移。最近,细胞自噬被认为在肿瘤发生和转移过程中具有重要的作用。同时,雄激素受体(AR)的下调在前列腺癌细胞中能够诱导细胞自噬。然而,潜在的机制仍旧不清楚。最近,有研究人员探索了内皮细胞在前列腺癌恶化中的作用和机制。研究人员建立了共培养系统来测试内皮细胞对前列腺癌细胞的影响。研究人员还进行了抗体试验和ELISA

Nature Biomedical Engineering:突破!纳米颗粒抗击前列腺癌!抑癌因子被恢复!

根据神刊CA刚刚发布的全球癌症统计报告2018,前列腺癌在男性肿瘤的发病和致死率中均排行前5名。这种发病和致死率均十分高的肿瘤困扰着全球数千万的老年男性。来自布里格姆妇女医院和波士顿儿童医院的研究小组与Memorial Sloan Kettering癌症中心的科研人员利用纳米颗粒开发出一种全新的抑癌方法, 他们通过重新赋予像PTEN和p53等肿瘤抑制因子的功能进而达到减缓前列腺癌的进展。该团队最新

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