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J Hepatol：正电子发射断层摄影术与18F -氟化氢的计算机断层摄影术可以改善肝癌患者的肿瘤分期和治疗配置

2018-03-17 MedSci MedSci原创

Fluorodeoxyglucose肝癌修正治疗方案
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双示踪PET/CT在特定情况下也可能有用(AFP的不明原因上升，可疑病变或未激活HCC患者的预移植评估)

研究背景：基于常规的成像依据BCLC分类对肝细胞癌(HCC)进行分期。本研究的目的是评估双示踪剂18F -氟化林和18F-FDG PET/CT对肿瘤分期和治疗分配的影响。

研究方法：对177例肝细胞癌患者进行双示踪剂18F -氟化林和18F-FDG PET/CT检查。回顾性收集基于传统影像学的BCLC分期和治疗方案；基于双示踪PET/CT检测，发现新的病变，BCLC分类或治疗分配将进行改变。

研究结果：参与研究的患者87.5%的为男性，其中71%的男性患者存在肝硬化。肝硬化的病因为酒精+/-酒精性脂肪性肝病(26%)、病毒性感染(62%)和未知病因(12%)。122例进行PET/CT检查的患者基于传统的影响学进行肝癌分期，61例患者(50%)为0/A， 32例患者（26%）为B 和29例患者(24%)为C期。双示踪PET-CT在26例患者中发现新的病变(21%)，14例患者(11%)BCLC分期增加，17例(14%)患者修正治疗策略。此外，双示踪PET/CT修正了44%(4/9)的不可解释的AFP升高的患者、40%(10/25)有可疑病变的常规显像患者和8% (3/36)等待肝移植的患者的最终治疗方案。

研究结论：双示踪PET/CT在特定情况下也可能有用(AFP的不明原因上升，可疑病变或未激活HCC患者的预移植评估)。

原始出处

Chalaye J， Costentin CE， Luciani A， et al. Positron emission tomography/computed tomography with 18F-fluorocholine improve tumor staging and treatment allocation in patients with hepatocellular carcinoma.J Hepatol， 2018， Mar 5. pii： S0168-8278(18)30136-3. doi： 10.1016/j.jhep.2018.02.018.

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    2018-04-06 仁心济世

    #计算机断层摄影术#

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    2018-05-20 zhu_jun9837

    #肝癌患者#

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    2018-07-27 12498c32m79暂无昵称

    #肿瘤分期#

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    2018-07-31 bioon14

    #计算机#

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    2018-03-19 gwc384

    #EPA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1812846, encodeId=472618128465b, content=<a href='/topic/show?id=bd5a9116422' target=_blank style='color:#2F92EE;'>#计算机断层摄影术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91164, encryptionId=bd5a9116422, topicName=计算机断层摄影术)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Fri Apr 06 15:02:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969010, encodeId=53ed19690108d, content=<a href='/topic/show?id=4dd7812e8f3' target=_blank style='color:#2F92EE;'>#肝癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81278, encryptionId=4dd7812e8f3, topicName=肝癌患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Sun May 20 13:02:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740296, encodeId=2cd01e4029663, content=<a href='/topic/show?id=94dc8283e23' target=_blank style='color:#2F92EE;'>#肿瘤分期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82837, encryptionId=94dc8283e23, topicName=肿瘤分期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cac734724454, createdName=12498c32m79暂无昵称, createdTime=Fri Jul 27 10:02:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716392, encodeId=228c1e16392b8, content=<a href='/topic/show?id=d68d911542f' target=_blank style='color:#2F92EE;'>#计算机#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91154, encryptionId=d68d911542f, topicName=计算机)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=def632217870, createdName=bioon14, createdTime=Tue Jul 31 17:02:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427044, encodeId=1074142e04455, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Mon Mar 19 12:02:00 CST 2018, time=2018-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297180, encodeId=f59829e1805e, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Mar 17 22:09:29 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-17 sunfeifeiyang

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