Heart：慢性免疫介导的炎症性疾病与心血管风险之间的相关性分析！

2017-08-29 xing.T MedSci原创

由此可见，全身结缔组织病和风湿性关节炎的心血管风险最大，对人群影响最大，其次是炎症性肠病。

近日，在心脏病领域权威杂志Heart上发表了一篇研究文章，研究人员旨在评估慢性免疫介导性疾病（类风湿性关节炎、系统性红斑狼疮或慢性免疫介导的炎症诊断群：炎症性肠道疾病、炎性多关节病、全身结缔组织疾病）与6年冠状动脉疾病、卒中、心血管疾病发病率和死亡率之间的相关性；并且评估每种慢性免疫介导的炎症性疾病所有四个终点的人群归因分数。

研究人员对加泰罗尼亚（西班牙）35岁至85岁无心血管病史的个人进行了一项队列研究。使用验证的编码来诊断慢性免疫介导性疾病和心血管疾病，从行政资料中获得死亡日期。在调整了性别、年龄、心血管疾病的危险因素和进一步调整用药剂量后，研究人员采用Cox回归模型来估计风险比，并估计每个暴露因素的人群归因分数。

研究人员共收集了991546名参与者的数据。全身性结缔组织疾病（模型1：HR为1.38（95%CI为1.21至1.57）以及模型2：HR为1.31（95%CI为1.15至1.49））、类风湿性关节炎（HR为1.43（95%CI为1.26至1.62），以及HR=1.31（95%CI为1.15至1.49））和炎症性肠病（HR为1.18（95%CI为1.06至1.32）以及HR=1.12（95%CI为1.01至1.25））患者增加了心血管疾病的风险。抗炎治疗的效果在所有疾病中较为显著（分别有HR=1.50（95%CI为1.24至1.81）；HR=1.47（95%CI为1.23至1.75）和HR=1.43（95%CI为1.19至1.73））。三种疾病的人群归因分数分别为13.4%、15.7%和10.7%。

由此可见，全身结缔组织病和风湿性关节炎的心血管风险最大，对人群影响最大，其次是炎症性肠病。

原始出处：

Jose Miguel Baena-Díez,et al. Association between chronic immune-mediated inflammatory diseases and cardiovascular risk. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-311279

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2018-02-18 ms9651749636653578

#炎症性疾病#

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time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622888, encodeId=14fa162288851, content=<a href='/topic/show?id=b6052895168' target=_blank style='color:#2F92EE;'>#免疫介导的炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28951, encryptionId=b6052895168, topicName=免疫介导的炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 31 07:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238382, encodeId=f41623838258, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, 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2017-08-31 zhaojie88

#ART#

93 0
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time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622888, encodeId=14fa162288851, content=<a href='/topic/show?id=b6052895168' target=_blank style='color:#2F92EE;'>#免疫介导的炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28951, encryptionId=b6052895168, topicName=免疫介导的炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 31 07:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238382, encodeId=f41623838258, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Aug 29 17:34:46 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
2017-08-31 anminleiryan

#相关性分析#

87 0
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time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622888, encodeId=14fa162288851, content=<a href='/topic/show?id=b6052895168' target=_blank style='color:#2F92EE;'>#免疫介导的炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28951, encryptionId=b6052895168, topicName=免疫介导的炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 31 07:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238382, encodeId=f41623838258, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Aug 29 17:34:46 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
2017-08-31 12498dd9m15暂无昵称

#炎症性#

78 0
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time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622888, encodeId=14fa162288851, content=<a href='/topic/show?id=b6052895168' target=_blank style='color:#2F92EE;'>#免疫介导的炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28951, encryptionId=b6052895168, topicName=免疫介导的炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Thu Aug 31 07:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238382, encodeId=f41623838258, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Aug 29 17:34:46 CST 2017, time=2017-08-29, status=1, ipAttribution=)]
2017-08-31 slcumt

#HEART#

82 0
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2017-08-31 爆笑小医

#免疫介导的炎症性疾病#

87 0
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2017-08-29 1ddf0692m34(暂无匿称)

学习了.涨知识

110 0

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