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Eur Heart J:线粒体多态性或影响心脏移植预后

2011-09-06 MedSci原创 MedSci原创

  来自西班牙的一项研究证实,线粒体单倍型类群可能是西班牙心脏移植人群终末期心衰进展的危险因素。此外,线粒体DNA(mtDNA)变异或对心脏移植并发症的发生造成一定影响。该研究2011年8月6日在线发表于《欧洲心脏杂志》(Eur Heart J)。   线粒体单倍型类群已知能够影响个体对广谱代谢性和退行性疾病的易感性,其中包括缺血性心血管疾病。研究评价了mtDNA背景对接受心

  来自西班牙的一项研究证实,线粒体单倍型类群可能是西班牙心脏移植人群终末期心衰进展的危险因素。此外,线粒体DNA(mtDNA)变异或对心脏移植并发症的发生造成一定影响。该研究2011年8月6日在线发表于《欧洲心脏杂志》(Eur Heart J)。

  线粒体单倍型类群已知能够影响个体对广谱代谢性和退行性疾病的易感性,其中包括缺血性心血管疾病。研究评价了mtDNA背景对接受心脏移植患者终末期心衰进展的影响。同时,还观察了mtDNA单倍型类群对移植相关并发症、主要心脏同种异体移植物血管病变(CAV)和移植后生存的影响。根据450 例心脏移植受者,248例心脏移植供者和206例健康对照者的基因型分析欧洲人群最常见的线粒体单倍型类群。线粒体单倍型类群通过短mtDNA片段的聚合酶链式反应(PCR)扩增,继而采用限制断片长度多态体分析加以确定。

  结果表明,在校正年龄和性别因素后,心脏移植受者中单倍型类群H出现的频率较对照组[比值比(OR)为1.86,95%可信区间(CI)为1.27–2.74,P= 0.014]和心脏供者(OR为1.47,95% CI为0.99–2.19,P= 0.032)显著升高。同样,单倍型类群Uk出现的频率在具有CAV的心脏同种异体移植受者较无CAV受者显著升高(OR为4.1,95% CI为1.51–11.42,P= 0.042)。最后,心脏供者的单倍型类群对心脏移植后的发病率或死亡率没有影响。

  链接:

  Mitochondrial haplogroups associated with end-stage heart failure and coronary allograft vasculopathy in heart transplant patients

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    2011-09-08 zhaojie88
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    2011-09-08 slcumt
  3. [GetPortalCommentsPageByObjectIdResponse(id=1355673, encodeId=9ff513556e38a, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Sep 08 13:44:00 CST 2011, time=2011-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562100, encodeId=50f11562100e9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Sep 08 13:44:00 CST 2011, time=2011-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629172, encodeId=c3f016291e29d, content=<a href='/topic/show?id=0c1c4325170' target=_blank style='color:#2F92EE;'>#多态性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43251, encryptionId=0c1c4325170, topicName=多态性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d83c21331263, createdName=xzw120, createdTime=Thu Sep 08 13:44:00 CST 2011, time=2011-09-08, status=1, ipAttribution=)]
    2011-09-08 xzw120
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