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J Cell Physiol：P2X7或是骨关节疾病的关键调节因子和潜在靶点

2018-10-17 MedSci MedSci原创

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大量证据表明，P2X7受体在人类健康和某些人类疾病中起着重要作用，包括高血压、动脉粥样硬化、肺部炎症、结核感染、精神疾病和癌症。P2X7受体在一些中枢神经系统疾病，如神经退行性疾病中也具有重要作用。最近，更多研究表明P2X7受体在骨关节疾病中也起着至关重要的作用。但P2X7受体对骨骼和关节疾病的影响尚未得到系统评价。 在本文中，研究人员详细阐述了P2X7受体在骨骼和关节疾病中的作用。P2X7

大量证据表明，P2X7受体在人类健康和某些人类疾病中起着重要作用，包括高血压、动脉粥样硬化、肺部炎症、结核感染、精神疾病和癌症。P2X7受体在一些中枢神经系统疾病，如神经退行性疾病中也具有重要作用。最近，更多研究表明P2X7受体在骨关节疾病中也起着至关重要的作用。但P2X7受体对骨骼和关节疾病的影响尚未得到系统评价。

在本文中，研究人员详细阐述了P2X7受体在骨骼和关节疾病中的作用。P2X7受体的激活可以通过诱导破骨细胞再吸收和成骨细胞骨形成之间的精细平衡来改善骨质疏松症。P2X7受体的激活可以通过增加对机械负荷的响应和诱导成骨来减轻应力性骨折损伤。但P2X7受体的激活介导骨癌中的细胞生长和细胞增殖。此外，P2X7受体的激活可加重一些关节疾病的过程，例如骨关节炎、类风湿性关节炎和急性痛风性关节炎。P2X7受体的抑制可以在一定程度上缓解关节病的病理过程。

总之，该研究表明P2X7受体可能是骨关节疾病的关键调节因子和治疗靶点。

原始出处：

Zeng D, Yao P, Zhao H. P2X7, a critical regulator and potential target for bone and joint diseases. J Cell Physiol. 2018 Oct 14. doi: 10.1002/jcp.27544.

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    2019-09-13 lisa438

    #骨关节#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2026595, encodeId=dd9620265952e, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Fri Sep 13 07:02:00 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870934, encodeId=556618e09340c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Dec 02 17:02:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961206, encodeId=d3ad196120655, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 23 01:02:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788882, encodeId=8cb21e88882e6, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Mar 08 23:02:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969266, encodeId=7016196926684, content=<a href='/topic/show?id=10e09205572' target=_blank style='color:#2F92EE;'>#调节因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92055, encryptionId=10e09205572, topicName=调节因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Mon Jul 08 04:02:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349677, encodeId=dce13496e73b, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Wed Oct 17 23:07:27 CST 2018, time=2018-10-17, status=1, ipAttribution=)]
    2018-12-02 hb2008ye

    #Cell#

    0

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    2019-09-23 维他命

    #CEL#

    0

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    2019-03-08 cmj8wellington

    #Physio#

    0

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    2019-07-08 liuli5079

    #调节因子#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2026595, encodeId=dd9620265952e, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Fri Sep 13 07:02:00 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870934, encodeId=556618e09340c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Dec 02 17:02:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961206, encodeId=d3ad196120655, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 23 01:02:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788882, encodeId=8cb21e88882e6, content=<a href='/topic/show?id=866d1421e4c' target=_blank style='color:#2F92EE;'>#Physio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14217, encryptionId=866d1421e4c, topicName=Physio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Mar 08 23:02:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969266, encodeId=7016196926684, content=<a href='/topic/show?id=10e09205572' target=_blank style='color:#2F92EE;'>#调节因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92055, encryptionId=10e09205572, topicName=调节因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Mon Jul 08 04:02:00 CST 2019, time=2019-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349677, encodeId=dce13496e73b, content=好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Wed Oct 17 23:07:27 CST 2018, time=2018-10-17, status=1, ipAttribution=)]
    2018-10-17 lietome24

    好文，值得点赞！认真学习，应用于实践！谢谢分享给广大同好！

    0

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