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Circulation:奎尼丁与多态性室性心动过速

2019-05-19 QQ MedSci原创

在无器质性心脏病(主要为特发性室颤和Brugada综合征)和急性WT段抬高型心肌梗死患者中,无QT延长的多态性室性心动过速(VT)有很好的描述。Sami Viskin等人回顾性研究发现多态性VT患者与冠状动脉疾病相关,但无急性心肌缺血的证据。研究人员筛查出43位患者在非复杂性心肌梗死或冠脉搭桥术后后几天内出现多型性VT。多态性VT均由短(364±36ms)耦合间期的额外收缩所触发。23例(53%)

在无器质性心脏病(主要为特发性室颤和Brugada综合征)和急性WT段抬高型心肌梗死患者中,无QT延长的多态性室性心动过速(VT)有很好的描述。

Sami Viskin等人回顾性研究发现多态性VT患者与冠状动脉疾病相关,但无急性心肌缺血的证据。

研究人员筛查出43位患者在非复杂性心肌梗死或冠脉搭桥术后后几天内出现多型性VT。多态性VT均由短(364±36ms)耦合间期的额外收缩所触发。23例(53%)患者发生心律不齐风暴(4-16次多型性VT恶化成室颤)。传统的抗心律不齐疗法难以逆转心律不齐风暴,包括静脉注射胺碘酮,但奎尼丁治疗有效。心律不齐风暴患者的院内死亡率高达17%。奎尼丁治疗的患者均活着出院。在长期的随访过程中(5.6±6年,范围:1个月-18年),未采用奎尼丁治疗的患者中有3位(16%)复发多态性VT。在奎尼丁治疗期间,无复发心律不齐。

奎尼丁可有效治疗对其他抗心律失常药物无反应的发生心律不齐风暴和复发性多型性VT的冠心病患者。

原始出处:

Sami Viskin,et al.Quinidine-Responsive Polymorphic Ventricular Tachycardia in Patients With Coronary Heart Disease. Circulation. 14 May 2019. https://doi.org/10.1161/CIRCULATIONAHA.118.038036.

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