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Thorax：肺部微生物纵向分析可证实细菌性和嗜酸细胞性COPD加重的反复性！

2018-02-02 xing.T MedSci原创

肺部微生物纵向分析细菌性嗜酸细胞性COPD加重反复性
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由此可见，COPD的亚型具有明显的细菌组成和随时间变化的稳定性。一些恶化的亚型在将来重复这些亚型时具有非随机可能性。这项研究为区分患者COPD亚型并确定合适的治疗方法提供了相关的肺部细菌靶点。

肺脏微生物组成改变与不良临床结局相关，这种改变称为菌群失调，其参与了疾病的严重程度和COPD的加重。近日，胸部疾病领域权威杂志Thorax上发表了一篇研究文章，该研究旨在归纳AERIS 研究（COPD急性加重期和呼吸道感染研究）参与者肺脏中微生物的纵向变化，以及其与相关COPD结局之间的关系。

研究人员利用高通量16S核糖体RNA基因测序对取自于101例COPD 患者的584份痰标本分析稳定期和急性加重期的肺脏微生物。研究人员将额外的肺部微生物学、血液标志物和深入的临床评估纳入COPD表型的分类。

肺脏微生物随时间推移的稳定性在急性加重期和频繁加重的患者中更可能降低。使用马尔可夫链模型分析急性加重症状表型发现细菌和嗜酸粒细胞增多的恶化更可能在随后的急性发作中反复出现，而病毒引起的疾病恶化则不太可能重复。研究人员也证实了细菌，包括流感嗜血杆菌和莫拉菌在内，与疾病的严重程度、加重事件和支气管扩张相关。

由此可见，COPD的亚型具有明显的细菌组成和随时间变化的稳定性。一些恶化的亚型在将来重复这些亚型时具有非随机可能性。这项研究为区分患者COPD亚型并确定合适的治疗方法提供了相关的肺部细菌靶点。

原始出处：

David Mayhew, et al. Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations.Thorax. 2018. http://dx.doi.org/10.1136/thoraxjnl-2017-210408

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    2018-11-12 lqrandywkz

    #细胞性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1805139, encodeId=c1601805139cc, content=<a href='/topic/show?id=3138e790655' target=_blank style='color:#2F92EE;'>#细胞性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77906, encryptionId=3138e790655, topicName=细胞性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon Nov 12 06:19:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824880, encodeId=9f881824880eb, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Dec 23 00:19:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304968, encodeId=4ac030496852, content=肺部和肠部都是微生物群所在地, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Thu Apr 12 06:00:45 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286859, encodeId=072f286859f4, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Feb 10 21:23:29 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285140, encodeId=45f0285140c3, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Feb 04 21:37:54 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284539, encodeId=d58528453966, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6aff2080448, createdName=1371f20e09m, createdTime=Fri Feb 02 21:50:34 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
    2018-12-23 wjcjjian

    #微生物#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1805139, encodeId=c1601805139cc, content=<a href='/topic/show?id=3138e790655' target=_blank style='color:#2F92EE;'>#细胞性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77906, encryptionId=3138e790655, topicName=细胞性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon Nov 12 06:19:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824880, encodeId=9f881824880eb, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Dec 23 00:19:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304968, encodeId=4ac030496852, content=肺部和肠部都是微生物群所在地, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Thu Apr 12 06:00:45 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286859, encodeId=072f286859f4, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Feb 10 21:23:29 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285140, encodeId=45f0285140c3, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Feb 04 21:37:54 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284539, encodeId=d58528453966, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6aff2080448, createdName=1371f20e09m, createdTime=Fri Feb 02 21:50:34 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
    2018-04-12 871538379

    肺部和肠部都是微生物群所在地

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1805139, encodeId=c1601805139cc, content=<a href='/topic/show?id=3138e790655' target=_blank style='color:#2F92EE;'>#细胞性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77906, encryptionId=3138e790655, topicName=细胞性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon Nov 12 06:19:00 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824880, encodeId=9f881824880eb, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Dec 23 00:19:00 CST 2018, time=2018-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304968, encodeId=4ac030496852, content=肺部和肠部都是微生物群所在地, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Thu Apr 12 06:00:45 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286859, encodeId=072f286859f4, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Feb 10 21:23:29 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=285140, encodeId=45f0285140c3, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Feb 04 21:37:54 CST 2018, time=2018-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284539, encodeId=d58528453966, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6aff2080448, createdName=1371f20e09m, createdTime=Fri Feb 02 21:50:34 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
    2018-02-10 天涯183

    非常好的文章.学习了

    0

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    2018-02-04 虈亣靌

    学习了.谢谢作者分享!

    0

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    2018-02-02 1371f20e09m

    学习了

    0

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