Diabetes Care：低血糖与室性心率失常风险增高有关

2013-09-25 佚名丁香园

在2型糖尿病合并心血管疾病（CVD）的患者中，胰岛素和/或磺酰脲类强化治疗可能与低血糖事件风险过度升高相关。为了评价危险的心律失常与血糖变异性的相关性，来自卡尔。古斯塔夫。卡鲁斯大学医院的Stahn博士等对2型糖尿病合并CVD患者进行了一项观察性研究。研究发现，严重低血糖事件与严重室性心率失常风险增高有关。研究结果在线发表于2013年9月16日的美国《糖尿病治疗》（

在2型糖尿病合并心血管疾病（CVD）的患者中，胰岛素和/或磺酰脲类强化治疗可能与低血糖事件风险过度升高相关。为了评价危险的心律失常与血糖变异性的相关性，来自卡尔。古斯塔夫。卡鲁斯大学医院的Stahn博士等对2型糖尿病合并CVD患者进行了一项观察性研究。研究发现，严重低血糖事件与严重室性心率失常风险增高有关。研究结果在线发表于2013年9月16日的美国《糖尿病治疗》（Diabetes Care）杂志上。【原文下载】

研究对象为30名经胰岛素和/或磺酰脲类（SU）治疗的2型糖尿病合并确诊的CVD患者，连续5天使用CGMS监测血糖，并平行进行ECG记录以监测室性心率失常。12名确诊CVD并经二甲双胍和/或DPP4抑制剂治疗且匹配的患者作为对照。患者治疗稳定，并被嘱咐分别注意心率失常和低血糖症状。

结果显示，经胰岛素和/或SU治疗的患者，无症状严重低血糖事件（<3.1 mmol/l）的发生率较高，而对照组患者没有发生严重低血糖。12名严重低血糖患者发生严重室性心率失常的频率较高，与没有严重低血糖的患者比较，分别为：室性偶联41.7±81.8 vs 5.5±16.7；室性心动过速：1.0 ± 1.9 vs. 0.1 ± 0.3.未观察到不同血糖值、QTc和室性心率失常有直接的相关性。

研究结果表明，严重低血糖事件与严重室性心率失常风险增高有关。

原文下载

Stahn A, Pistrosch F, Ganz X, Teige M, Koehler C, Bornstein S, Hanefeld M.Relationship between hypoglycemic episodes and ventricular arrhythmias in patients with type 2 diabetes and cardiovascular diseases.Diabetes Care. 2013 Sep 16.

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2014-06-30 zhouqu_8

#Diabetes#

73 0
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2013-11-18 pps20026

#心率失常#

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2014-06-25 ms5439512287675881

#BET#

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2014-05-08 ms9608593228839890

#DIA#

76 0
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2013-09-27 liuxiaona

#增高#

91 0
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2013-09-27 liuxiaona

#增高#

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