Baidu
map

神经科

订阅

MedSci主页 / 所有栏目 / 神经科

Nature：外伤性脑损伤的治疗方法

2014-01-14 Nature中文网 Nature中文网

外伤性脑损伤
关注

外伤性脑损伤（经常是由交通事故造成的）是一个主要杀手和神经疾病的一个病因。 这项研究描述了一个闭锁性颅骨骨折小鼠模型，其病理与人类轻度外伤性脑损伤相似。 本文作者利用长期活体显微镜方法来研究从受伤开始起的损伤反应动态。他们利用该模型发现，实质细胞和脑膜细胞死亡可以通过“嘌呤能受体”对抗剂和抗氧化剂“谷胱甘肽”进行局部治疗来减少。 原文出处 Roth TL, Nayak D, Atanasi

外伤性脑损伤（经常是由交通事故造成的）是一个主要杀手和神经疾病的一个病因。【原文下载】

这项研究描述了一个闭锁性颅骨骨折小鼠模型，其病理与人类轻度外伤性脑损伤相似。

本文作者利用长期活体显微镜方法来研究从受伤开始起的损伤反应动态。他们利用该模型发现，实质细胞和脑膜细胞死亡可以通过“嘌呤能受体”对抗剂和抗氧化剂“谷胱甘肽”进行局部治疗来减少。

原文出处

Roth TL, Nayak D, Atanasijevic T, Koretsky AP, Latour LL, McGavern DB.Transcranial amelioration of inflammation and cell death after brain injury.Nature. 2014 Jan 9【原文下载】

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1879853, encodeId=527d18e9853cb, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 18 04:53:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992205, encodeId=397119922051e, content=<a href='/topic/show?id=a6d842e5938' target=_blank style='color:#2F92EE;'>#外伤性脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42759, encryptionId=a6d842e5938, topicName=外伤性脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Mar 18 13:53:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022354, encodeId=82e42022354fa, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Wed Jan 29 21:53:00 CST 2014, time=2014-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396805, encodeId=018b13968052e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399168, encodeId=9c25139916855, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=)]
    2014-04-18 liye789132251

    #Nat#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1879853, encodeId=527d18e9853cb, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 18 04:53:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992205, encodeId=397119922051e, content=<a href='/topic/show?id=a6d842e5938' target=_blank style='color:#2F92EE;'>#外伤性脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42759, encryptionId=a6d842e5938, topicName=外伤性脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Mar 18 13:53:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022354, encodeId=82e42022354fa, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Wed Jan 29 21:53:00 CST 2014, time=2014-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396805, encodeId=018b13968052e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399168, encodeId=9c25139916855, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=)]
    2014-03-18 jktdtl

    #外伤性脑损伤#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1879853, encodeId=527d18e9853cb, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 18 04:53:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992205, encodeId=397119922051e, content=<a href='/topic/show?id=a6d842e5938' target=_blank style='color:#2F92EE;'>#外伤性脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42759, encryptionId=a6d842e5938, topicName=外伤性脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Mar 18 13:53:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022354, encodeId=82e42022354fa, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Wed Jan 29 21:53:00 CST 2014, time=2014-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396805, encodeId=018b13968052e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399168, encodeId=9c25139916855, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=)]
    2014-01-29 ms7405317358118777

    #外伤性#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1879853, encodeId=527d18e9853cb, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 18 04:53:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992205, encodeId=397119922051e, content=<a href='/topic/show?id=a6d842e5938' target=_blank style='color:#2F92EE;'>#外伤性脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42759, encryptionId=a6d842e5938, topicName=外伤性脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Mar 18 13:53:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022354, encodeId=82e42022354fa, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Wed Jan 29 21:53:00 CST 2014, time=2014-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396805, encodeId=018b13968052e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399168, encodeId=9c25139916855, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=)]
    2014-01-16 智者为医08

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1879853, encodeId=527d18e9853cb, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 18 04:53:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1992205, encodeId=397119922051e, content=<a href='/topic/show?id=a6d842e5938' target=_blank style='color:#2F92EE;'>#外伤性脑损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42759, encryptionId=a6d842e5938, topicName=外伤性脑损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Mar 18 13:53:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022354, encodeId=82e42022354fa, content=<a href='/topic/show?id=cfef42e57fa' target=_blank style='color:#2F92EE;'>#外伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42757, encryptionId=cfef42e57fa, topicName=外伤性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, createdName=ms7405317358118777, createdTime=Wed Jan 29 21:53:00 CST 2014, time=2014-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396805, encodeId=018b13968052e, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399168, encodeId=9c25139916855, content=<a href='/topic/show?id=cac364650c0' target=_blank style='color:#2F92EE;'>#治疗方法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64650, encryptionId=cac364650c0, topicName=治疗方法)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8cec2200006, createdName=showtest, createdTime=Thu Jan 16 04:53:00 CST 2014, time=2014-01-16, status=1, ipAttribution=)]
    2014-01-16 showtest

    #治疗方法#

    0

相关资讯

Brain Inj：SLC6A4基因变体与创伤后抑郁发病有关

　　导致创伤后抑郁（PTD）的因素包括，继发性损伤的化学级联及外伤性脑损伤（TBI）后的精神社会因素等。当前，对5-羟色胺在病理学中的作用及原发性抑郁症的治疗还存在一定的争议，且5-羟色胺在TBI继发PTD中可能发挥的作用尚不明确。 　　近期发表在Brain Inj上一项研究对羟色胺的功能及TBI后一年内发生PTD的遗传性风险进行了评估。研究发现TBI与抑郁症的风险基因之间存在一种独特的具有损伤

Baidu
map
Baidu
map
Baidu
map