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Pharmacological Research: 连花清瘟体外试验显示抗新冠病毒抗炎作用

2020-03-24 科学网 科学网

中国工程院院士钟南山团队最新研究认为,连花清瘟在体外试验中显示出抗新冠病毒的作用。

中国工程院院士钟南山团队最新研究认为,连花清瘟在体外试验中显示出抗新冠病毒的作用。

相关论文题为《连花清瘟对新型冠状病毒具有抗病毒、抗炎作用》“Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)”,已被《药理学研究》期刊(Pharmacological Research)接收。

论文作者包括广州医科大学呼吸疾病国家重点实验室主任钟南山、研究员杨子峰等。

论文提到,作为一种中药方剂,连花清瘟对一系列流感病毒具有广谱抗病毒作用和免疫调节作用。

研究人员使用CPE和空斑减数实验,在Vero E6细胞中评估了连花清瘟对SARS-CoV-2的抗病毒活性。

在透射电子显微镜下可见连花清瘟对病毒体形态的影响。

通过实时定量PCR测定法测量Huh-7细胞中SARS-CoV-2感染后促炎细胞因子的表达水平。

试验结果表明,连花清瘟在mRNA水平上显著抑制SARS-CoV-2在Vero E6细胞中的复制,并显著降低促炎细胞因子(TNF-α,IL-6,CCL-2 / MCP-1和CXCL-10 / IP-10)的产生。此外,连花清瘟处理导致细胞中病毒粒子的颗粒形态异常。

论文总结道,连花清瘟显著抑制SARS-COV-2复制,影响病毒形态并在体外发挥抗炎活性。这表明连花清瘟可以抵抗病毒攻击,有望成为控制COVID-19疾病的新策略。

原始出处:
Li RunFeng,et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2).Pharmacological Research. 20 Martch, 2020

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    2020-11-25 lovetcm

    #连花清瘟胶囊#,这是#钟南山#院士做的研究成果,说实话,这个研究水平是相当低的,而且仅仅是#体外研究#,与临床研究完全不一样,也根本无法说明连花清瘟胶囊能够对抗#新冠肺炎#。但是,也不能苛求,就中药企业而言,这家公司已经是最好的了。再怎么说,人家还拿出一点证据,至少比#双黄连#强上很多倍

    0

  4. 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    2020-12-31 yb6560
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  8. 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  9. 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    2020-03-24 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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