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Am J Kidney Dis:心源性疾病或是肾梗死的重要原因

2016-04-03 徐媛 MedSci原创

肾梗塞是一种罕见的疾病,肾动脉及其分支血流急剧中断可导致肾梗塞,由心脏或近端主动脉栓子脱落,腹部创伤或肾动脉病变所致,但有关肾梗塞的致病原因和预后尚不十分清楚。 研究人员收纳了来自韩国的1993年1月至2013年12月9日年间的438名肾梗塞患者。通过影像学检查(CT、MRI和/或放射性同位素扫描)显示肾实质内单个或多个楔形的血流灌注缺损来定义肾梗塞。 研究人员将患者分为4组:心源性疾病组(n

肾梗塞是一种罕见的疾病,肾动脉及其分支血流急剧中断可导致肾梗塞,由心脏或近端主动脉栓子脱落,腹部创伤或肾动脉病变所致,但有关肾梗塞的致病原因和预后尚不十分清楚。

研究人员收纳了来自韩国的1993年1月至2013年12月9日年间的438名肾梗塞患者。通过影像学检查(CT、MRI和/或放射性同位素扫描)显示肾实质内单个或多个楔形的血流灌注缺损来定义肾梗塞。

研究人员将患者分为4组:心源性疾病组(n = 244[55.7%]),肾动脉损伤组(n = 33[7.5%]),高凝状态组(n = 29[6.6%])和特发性病因组(n = 132[30.1%])。将肾梗塞复发率、急性肾损伤(AKI,定义为血肌酐水平48 h内升高 ≥ 0.3 mg/dL或住院7天内血肌酐水平升至基线水平的150%)发生率、肾梗塞后3个月新发估算肾小球滤过率(eGFR)< 60 ml/min/1.73m2、终末期肾病(ESRD,定义为不可逆的肾脏损伤需接受血液透析或腹膜透析治疗)发生率和死亡率作预后评价指标。

治疗方法包括尿激酶(n = 19)、肝素(n = 342)、华法林(n = 330)、和抗血小板药物(n = 157)。初始住院过程中5%的患者死亡。在中位随访时间20个月(1-223个月)的随访过程中,2.8%的患者出现梗塞复发,20.1%的患者出现AKI,10.9%的患者出现新发eGFR < 60 ml/min/1.73m2,2.1%的患者进展至ESRD。

研究结果,尽管本项研究表明心源性疾病是肾梗死的最重要原因,而房颤是导致肾梗塞最为常见的病因,但这项研究不能清楚地确定具体的阐释肾梗塞的机制对某些患者的死亡原因。

原始出处

Oh YK1, Yang CW2, Kim YL3, Kang SW4, Park CW2, Kim YS5, Lee EY6, Han BG7, Lee SH8, Kim SH9, Lee H5, Lim CS10.Clinical Characteristics and Outcomes of Renal Infarction.Am J Kidney Dis. 2016 Feb

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    值得学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1814787, encodeId=da151814e87de, content=<a href='/topic/show?id=d007960622e' target=_blank style='color:#2F92EE;'>#重要原因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96062, encryptionId=d007960622e, topicName=重要原因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Mon Jan 16 07:10:00 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012086, encodeId=ded520120860b, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jul 14 22:10:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082275, encodeId=bcc720822e57d, content=<a href='/topic/show?id=9cd8825634c' target=_blank style='color:#2F92EE;'>#肾梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82563, encryptionId=9cd8825634c, topicName=肾梗死)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKjqGDO7icVKUiaT7urgwXvnvzWtp0fMFU46Xfib8oavFKygiaWtibXReS6ZUh3PImsNicGAwTO5HXxoicnA/132, createdBy=ee262500130, createdName=ms7474195563676018, createdTime=Sun Aug 21 23:10:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85448, encodeId=53958544817, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Wed May 11 07:06:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85449, encodeId=590d8544952, content=非常有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Wed May 11 07:06:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593421, encodeId=302c159342158, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Tue Apr 05 02:10:00 CST 2016, time=2016-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602960, encodeId=7ea916029602d, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Apr 05 02:10:00 CST 2016, time=2016-04-05, status=1, ipAttribution=)]
    2016-05-11 卡莲

    非常有用

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1814787, encodeId=da151814e87de, content=<a href='/topic/show?id=d007960622e' target=_blank style='color:#2F92EE;'>#重要原因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96062, encryptionId=d007960622e, topicName=重要原因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Mon Jan 16 07:10:00 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012086, encodeId=ded520120860b, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jul 14 22:10:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082275, encodeId=bcc720822e57d, content=<a href='/topic/show?id=9cd8825634c' target=_blank style='color:#2F92EE;'>#肾梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82563, encryptionId=9cd8825634c, topicName=肾梗死)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKjqGDO7icVKUiaT7urgwXvnvzWtp0fMFU46Xfib8oavFKygiaWtibXReS6ZUh3PImsNicGAwTO5HXxoicnA/132, createdBy=ee262500130, createdName=ms7474195563676018, createdTime=Sun Aug 21 23:10:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85448, encodeId=53958544817, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Wed May 11 07:06:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85449, encodeId=590d8544952, content=非常有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Wed May 11 07:06:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593421, encodeId=302c159342158, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Tue Apr 05 02:10:00 CST 2016, time=2016-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602960, encodeId=7ea916029602d, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Apr 05 02:10:00 CST 2016, time=2016-04-05, status=1, ipAttribution=)]
    2016-04-05 mhm295
  7. [GetPortalCommentsPageByObjectIdResponse(id=1814787, encodeId=da151814e87de, content=<a href='/topic/show?id=d007960622e' target=_blank style='color:#2F92EE;'>#重要原因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96062, encryptionId=d007960622e, topicName=重要原因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Mon Jan 16 07:10:00 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012086, encodeId=ded520120860b, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Jul 14 22:10:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082275, encodeId=bcc720822e57d, content=<a href='/topic/show?id=9cd8825634c' target=_blank style='color:#2F92EE;'>#肾梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82563, encryptionId=9cd8825634c, topicName=肾梗死)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKjqGDO7icVKUiaT7urgwXvnvzWtp0fMFU46Xfib8oavFKygiaWtibXReS6ZUh3PImsNicGAwTO5HXxoicnA/132, createdBy=ee262500130, createdName=ms7474195563676018, createdTime=Sun Aug 21 23:10:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85448, encodeId=53958544817, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Wed May 11 07:06:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85449, encodeId=590d8544952, content=非常有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Wed May 11 07:06:00 CST 2016, time=2016-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1593421, encodeId=302c159342158, content=<a href='/topic/show?id=9850510e9a3' target=_blank style='color:#2F92EE;'>#心源性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51079, encryptionId=9850510e9a3, topicName=心源性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=955718147815, createdName=mhm295, createdTime=Tue Apr 05 02:10:00 CST 2016, time=2016-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602960, encodeId=7ea916029602d, content=<a href='/topic/show?id=81b91049067' target=_blank style='color:#2F92EE;'>#kidney#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10490, encryptionId=81b91049067, topicName=kidney)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c36e18990621, createdName=gwc389, createdTime=Tue Apr 05 02:10:00 CST 2016, time=2016-04-05, status=1, ipAttribution=)]
    2016-04-05 gwc389
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