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Diabetologia：暗光损害大鼠葡萄糖耐受

2017-07-31 MedSci MedSci原创

暗光葡萄糖
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近几十年来，暗光（LAN）暴露急剧增加。动物研究表明慢性昏暗LAN导致肥胖和葡萄糖不耐受。此外，在人类的几项研究已经证明，长期接触人造LAN可能具有代谢紊乱风险增加如2型糖尿病等不利的健康影响。众所周知，急性暴露于LAN会影响生物钟功能，激素分泌和自主神经系统的活动，但缺乏LAN对葡萄糖体内平衡的影响的数据。本研究旨在调查LAN对葡萄糖代谢的急性影响。

近日，国际杂志 《Diabetologia》上在线发表一项关于暗光以时间，强度和波长依赖的方式严重损害大鼠葡萄糖耐受的研究。

近几十年来，暗光（LAN）暴露急剧增加。动物研究表明慢性昏暗LAN导致肥胖和葡萄糖不耐受。此外，在人类的几项研究已经证明，长期接触人造LAN可能具有代谢紊乱风险增加如2型糖尿病等不利的健康影响。众所周知，急性暴露于LAN会影响生物钟功能，激素分泌和自主神经系统的活动，但缺乏LAN对葡萄糖体内平衡的影响的数据。本研究旨在调查LAN对葡萄糖代谢的急性影响。

早期或晚期黑暗阶段暴露LAN 2小时的雄性Wistar大鼠进行注射葡萄糖或胰岛素耐量测试。在随后的实验中，使用不同的光强度和波长。

在ZT15的早期黑暗阶段的LAN暴露在葡萄糖输注后的前20分钟期间引起葡萄糖反应增加（p<0.001），而LAN暴露在黑暗结束时的ZT21，在前10分钟引起胰岛素反应增加（p<0.01），说明LAN立即引起大鼠葡萄糖不耐受。随后的实验表明，LAN的效应是强度和波长依赖的。50和150 lx的白光诱导比5和20 lx更大的葡萄糖反应，而除5 lx以外的所有强度降低了运动活性。绿光诱导葡萄糖不耐受，但红色和蓝色光没有，表明牵涉了特定的视网膜脑通路。

总而言之，这些数据表明，依赖于时间，强度和波的LAN暴露对葡萄糖代谢有急性副作用。

原始出处：

Anne-Loes Opperhuizen, Dirk J. Stenvers, Remi D. Jansen,et al. Light at night acutely impairs glucose tolerance in a time-, intensity- and wavelength-dependent manner in rats

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    2017-08-01 189****7206

    学习了受益匪浅

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