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J Gastroenterology:冠状动脉斑块形态学中肝脏脂肪变性的临床意义

2019-03-06 不详 MedSci原创

非酒精性脂肪性肝病(NAFLD)在冠状动脉粥样硬化中起重要作用,受控衰减参数(CAP)测量法已能够在亚临床阶段早期和非侵入性地检测NAFLD的发生。因此,本项研究的目的旨在评估CAP定义的NAFLD与冠状动脉斑块的相关性。

背景
非酒精性脂肪性肝病(NAFLD)在冠状动脉粥样硬化中起重要作用,受控衰减参数(CAP)测量法已能够在亚临床阶段早期和非侵入性地检测NAFLD的发生。因此,本项研究的目的旨在评估CAP定义的NAFLD与冠状动脉斑块的相关性。

方法
研究人员进行了一项回顾性队列研究,受试者均为健康体检患者,他们在健康体检期间进行了肝脏Fibroscan和冠状动脉计算机断层扫描(CT)。

结果
研究人员在冠状动脉斑块组中发现了更多具有CAP定义的NAFLD的受试者(61.3% VS 73.5%,p= 0.005)。根据多变量回归模型,在调整可能的混杂因素后,CAP≥222dB / m是与冠状动脉斑块存在相关的独立且显着的参数(OR 1.624,95%1.047-2.518,p= 0.030)。有趣的是,CAP≥222dB / m与非钙化斑块显着相关(调整OR 3.528,95%CI 1.463-8.511,p = 0.005)。

结论
本项研究表明CAP定义的NAFLD与冠状动脉斑块独立相关,尤其是非钙化斑块。

原始出处:

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    2019-07-17 许安
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  6. 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  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504615, encodeId=a36c1504615e2, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Mar 08 09:57:00 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603646, encodeId=742b1603646e2, content=<a href='/topic/show?id=0018814e070' target=_blank style='color:#2F92EE;'>#肝脏脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81470, encryptionId=0018814e070, topicName=肝脏脂肪)], attachment=null, 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    2019-03-08 huangdf
  8. 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