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FASEB J:第四军医大学发现血小板新功能

2018-02-08 佚名 生物通

经典血液理论认为血小板是维持血液凝集稳态的关键细胞,近年血小板在机体天然免疫等过程中的重要作用引起广泛关注。最近第四军医大学西京医院等研究机构在FASEB J杂志公布了一项新的研究结果,证实血小板能够独立发挥抑制细菌生长的功能。


经典血液理论认为血小板是维持血液凝集稳态的关键细胞,近年血小板在机体天然免疫等过程中的重要作用引起广泛关注。最近第四军医大学西京医院等研究机构在FASEB J杂志公布了一项新的研究结果,证实血小板能够独立发挥抑制细菌生长的功能。

2月7日,美国实验生物学联合会会刊The FASEB Journal杂志在线发表了题为“Platelets directly regulate DNA damage and division of Staphylococcus aureus”的研究论文,报道了高纯化血小板对金黄色葡萄球菌的直接抑制作用和机理。

经典血液学理论认为,血小板在机体止血过程中发挥关键作用,近年来发现血小板也参与新生血管形成以及天然免疫应答等过程。尽管有研究证实血小板可促进巨噬细胞、中性粒细胞等发挥吞噬、杀伤细菌功能,但关于血小板的直接抑菌作用及机制并不清楚。

该发表的论文中,研究者利用分离、纯化的人血小板和小鼠血小板,体外分别直接作用于金黄色葡萄球菌,加上单抗封闭策略建立的血小板缺失小鼠模型,系统证实了血小板对金黄色葡萄球菌的直接抑制作用;随后在RNA seq分析中发现血小板破坏了细菌DNA损伤修复的相关基因,质谱高通量分析和体内外实验证实,血小板来源的TGF-β1抑制了金葡菌DNA损伤修复。

该研究结果进一步证实了血小板在天然免疫防御中的重要生理功能,表明了血小板功能的复杂性,为人类科学和高效利用、研究血小板这一经典细胞指明了新方向。

来自第四军医大学西京医院的胡兴斌副教授和尹文教授为该研究的共同通讯作者,该小组的徐金梅和易静为本文的共同第一作者,其他合作者还包括重庆医科大学、美国哥伦比亚大学和美国City of Hope医学中心。胡兴斌副教授研究小组长期从事血液细胞发育和Niche功能解析研究、应用,和其合作者的研究成果先后在Nature Communications、Leukemia、Hepatology、Cancer Research、JBC、FASEB J等期刊上发表。

原始出处:

Jinmei Xu, et al.Platelets directly regulate DNA damage and division of Staphylococcus aureus.FASEB J.Ahead of Print07 Feb 2018

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    2018-05-15 gracezdd
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