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Circulation:研究发现可预防动脉硬化的蛋白质!

2017-07-15 枫丹白露 来宝网

DDK3可作为一种新的治疗方法,用于阻止动脉内脂肪物质的积聚



蛋白质可以防止心脏病发作】DDK3可作为一种新的治疗方法,用于阻止动脉内脂肪物质的积聚

伦敦国王学院研究人员的新研究显示,天然存在的蛋白质,dickkopf相关蛋白3(DKK3)可能成为防止动脉粥样硬化引起的心脏病发作和中风的关键

该研究由英国心脏基金会(BHF)资助并发表在“循环”杂志上,表明该蛋白质最终可用于预防心脏病发作和中风。

科学家测量了五年来从574人收集的血液样本中的DKK3水平。他们发现,DKK3水平较高的人在五年内不太可能发展动脉粥样硬化,也不太可能因心脏病发作或中风而死亡。

这种相关性与其他动脉粥样硬化危险因素如高血压胆固醇水平无关。

动脉粥样硬化是动脉内脂肪物质的积聚。当这种材料分解时,血块可以阻止心脏或大脑的血液供应,导致心脏病发作或中风。

DKK3蛋白质遗传缺陷的小鼠也比那些可以产生蛋白质的发展更大,更稳定的动脉粥样硬化斑块。

DKK3缺陷小鼠在损伤后也不太可能再生内皮衬里涂覆其血管。这表明,在任何脂肪沉积物积聚之前,DKK3能够通过帮助内皮衬里修复自身处于损伤的第一个迹象来保护免受动脉粥样硬化。

徐培波教授,伦敦国王学院BHF心理研究中心心血管科学主任John Parker说:“我们的工作表明,我们可以使用简单的血液检测来发现有心脏病发作风险的看似健康的人,他们的全科医生一般不会被确定为处于危险之中。

“最终也可能提高DDK3水平,并保护人们免受可能导致心脏病发作或中风的脂肪堆积。”

英国心脏基金会副医学主任杰里米·皮尔森教授说:“由于心脏病发作,英国每年有大约20万次医院访问。这项研究表明,有可能治疗这种破坏性疾病的根本原因,最终挽救生命。

“通过确定新的保护分子,这项研究可能会导致新的药物进一步降低心脏病发作的风险。”

原始出处:

Baoqi Yu, Stefan Kiechl, Dan Qi, et al. A Cytokine-like Protein DKK3 Is Atheroprotective. Circulation. 2017;CIRCULATIONAHA.117.027690, originally published July 3, 2017.

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    2017-07-17 nannanxyy

    好文,对思路有启发,谢谢分享

    0

  4. 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  5. 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createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Jul 15 09:39:20 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222510, encodeId=ddbc222510b0, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sat Jul 15 09:37:56 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222506, encodeId=d32422250641, content=继续关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 15 09:32:26 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 清风拂面

    很好的文章,谢谢分享

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 15 09:32:26 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 1e0f8808m18(暂无匿称)

    学习了,谢谢分享。

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 15 09:32:26 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 一露鹤笙

    路还很漫长呢…

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 15 09:32:26 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 大爰

    学习了谢谢分享!!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1765648, encodeId=148e1e6564842, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Feb 22 11:27:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1753237, encodeId=946f1e532372d, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 15 12:16:02 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222573, encodeId=72812225e3cd, content=路还很漫长呢…, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=4aca1635970, createdName=一露鹤笙, createdTime=Sat Jul 15 11:47:53 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222512, encodeId=809e222512f6, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 15 09:32:26 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 1e17414fm02(暂无匿称)

    学习

    0

  10. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jul 15 09:32:26 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 1dd8c52fm63(暂无匿称)

    继续关系

    0

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帕金森氏症中标志性的脑损伤被认为是一种错误折叠的恶性蛋白的“杰作”。这种蛋白会像传染病一样,在不同的脑细胞之间扩散。如今,研究人员发现,该蛋白(αS)的正常形式实际上或能通过汇集关键免疫细胞,保护肠道免受入侵者的破坏。不过,科学家表示,如果αS从肠壁中负荷过重的神经纤维迁移到大脑,慢性肠道感染可能最终导致帕金森氏症。

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