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DCR:I期至III期结肠癌根治术后低氯血症对于预后的影响

2018-11-16 MedSci MedSci原创

最近的研究表明,电解质紊乱可能是某些疾病的不良预后的危险因素。本研究的目的是系统地评估电解质紊乱对接受根治性手术切除的I期至III期结直肠癌患者的预后作用。

背景
最近的研究表明,电解质紊乱可能是某些疾病的不良预后的危险因素。本研究的目的是系统地评估电解质紊乱对接受根治性手术切除的I期至III期直肠癌患者的预后作用。

方法
本项研究是一项回顾性研究,纳入的是在2007年4月和2014年4月间行直肠癌根治性切除术的患者。主要观察指标:采用Kaplan-Meier方法评估总体和无病生存率。

结果
本项研究共招募了5089名符合条件的患者。在预匹配分析中,低氯血症患者的总生存期较短(HR = 0.943(95%CI,0.908-0.980);P= 0.003)和无病生存率(HR = 0.957(95%CI,0.933-0.981)P<0.001)。在匹配后分析中,对每组770名患者进行了比较,结果进一步证实,低氯血症与较差的总生存率显着相关(HR = 0.646(95%CI,0.489-0.855);p= 0.002)和无病生存率( HR = 0.782(95%CI,0.647-0.944);p= 0.01)。

结论
低氯血症的确会影响结肠癌切除患者的预后水平,整体和无病生存率都会受到不同程度的影响。

原始出处:

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    2019-02-15 juliusluan78
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    2018-11-18 jeanqiuqiu
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