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GUT:胰腺癌切除术的国际间差异研究!

2017-11-22 MedSci MedSci原创

对于能够切除的胰腺癌(PaC)患者进行手术切除可以使这部分患者得到治愈,并能够显着延长部分患者的生存期。近期,一项发表在杂志GUT上的大规模国际研究旨在调查欧洲和美国PaC切除的差异及其使用的决定因素。此项研究分析了2003-2016年期间,欧洲六个人口癌症登记处以及美国监测、流行病学和最终结果计划数据库的数据。计算了总体和I-II 期PaCs患者的年龄标准化切除率。切除与人口统计学和临床参数之间

对于能够切除的胰腺癌(PaC)患者进行手术切除可以使这部分患者得到治愈,并能够显着延长部分患者的生存期。


近期,一项发表在杂志GUT上的大规模国际研究旨在调查欧洲和美国PaC切除的差异及其使用的决定因素。

此项研究分析了2003-2016年期间,欧洲六个人口癌症登记处以及美国监测、流行病学和最终结果计划数据库的数据。计算了总体和I-II 期PaCs患者的年龄标准化切除率。切除与人口统计学和临床参数之间的关联使用多变量逻辑回归模型进行评估。

最终,此项研究共分析了153698条记录。在2012-2014年的人口基础登记中,总体切除率从Estonia的13.2%到Slovenia的21.2%;I-II期的切除率从Norway的34.8%到Denmark的68.7% 。

在2003-2014年期间,切除率只在美国、荷兰和丹麦地区上升。在进展期的肿瘤阶段(Ⅲ,Ⅳ期 vs Ⅰ-Ⅱ期肿瘤的OR值:各国0.05-0.18和0.01-0.06)以及年龄增加(70-79岁和≥80岁 vs. <60岁的ORs:各国为0.37-0.63和0.03-0.16)的人群中切除率更低。

很少接受切除的晚期肿瘤(III-IV期:63.8%-81.2%)和年龄较大(≥70岁:52.6%-59.5%)的患者占绝大多数的确诊病例。患者的疾病状况、肿瘤的位置和大小也与是否切除有关。

此项研究结果表明:在欧洲和美国,PaC的切除率仍然很低,并且,PaC的切除情况在国际上有很大的差异。

原始出处:
Huang L, Jansen L, et al. Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations. Gut. 2017 Nov 20. pii: gutjnl-2017-314828. doi: 10.1136/gutjnl-2017-314828. 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1876968, encodeId=164518e69680e, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Mar 13 06:34:00 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263512, encodeId=659d26351281, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/7e2c04a7e58b6065a1392efd799c6a6b.jpg, createdBy=de482077642, createdName=王晓霞, createdTime=Thu Nov 23 06:51:30 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263419, encodeId=b5a72634196b, content=谢谢分享学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Wed Nov 22 21:18:27 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263406, encodeId=f5a326340607, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Nov 22 19:55:05 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-23 王晓霞

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1876968, encodeId=164518e69680e, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Tue Mar 13 06:34:00 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263512, encodeId=659d26351281, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/7e2c04a7e58b6065a1392efd799c6a6b.jpg, createdBy=de482077642, createdName=王晓霞, createdTime=Thu Nov 23 06:51:30 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263419, encodeId=b5a72634196b, content=谢谢分享学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM7GibvIBibibnnnvpajk2stlDF5oichYahI6Bia8uxeTBFoPbdoHWebyXf9eal9FNgUF2lNcrwoZicM3BvQ/0, createdBy=a3742066385, createdName=戒馋,懒,贪, createdTime=Wed Nov 22 21:18:27 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263406, encodeId=f5a326340607, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Wed Nov 22 19:55:05 CST 2017, time=2017-11-22, status=1, ipAttribution=)]
    2017-11-22 戒馋,懒,贪

    谢谢分享学习了.

    0

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    2017-11-22 thlabcde

    好资料学习了!

    0

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