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Diabetes Care:肾功能正常或轻度受损的2型糖尿病患者成纤维细胞生长因子23与死亡率的关系

2019-10-10 xing.T MedSci原创

由此可见,在2型糖尿病且肾功能正常或轻度受损的患者中,FGF23水平与心血管事件和死亡风险增加有关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在探究肾功能正常或轻度受损的2型糖尿病患者成纤维细胞生长因子23(FGF23)水平是否与不良结局相关。

研究人员分析了310例估计的肾小球过滤率≥60mL/min/1.73m2的2型糖尿病患者FGF23的C末端水平,研究人员通过Cox回归分析了FGF23与全因死亡率和主要不良心血管事件(MACE)之间的相关性。

在5.8年(3.3-6.5)的随访期间,有47例受试者发展为MACE,28例受试者死亡。FGF23与全因死亡率(年龄和性别校正后的风险比为2.78[95%CI为1.76–4.40])和MACE(1.67[1.12-2.49])风险增加相关。在对其他潜在混杂因素进行进一步调整后,结果相似,并且在独立队列中进行重复试验后仍保持一致。

由此可见,在2型糖尿病且肾功能正常或轻度受损的患者中,FGF23水平与心血管事件和死亡风险增加有关。 

原始出处:


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  5. 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  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat Oct 12 06:03:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474833, encodeId=faa514e4833d0, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Sat Oct 12 06:03:00 CST 2019, time=2019-10-12, status=1, ipAttribution=)]
    2020-08-07 yese
  7. 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在T1D个体中,较高的UA水平与肾功能、CVE和死亡率下降的风险较高相关,而与其他危险因素无关。该研究结果表明,UA在T1D患者的危险分层中具有很好的作用。

JAHA:阿托伐他汀可通过改善肾功能降低心血管风险

肾功能会随着年龄变大而降低,这种降低对肾和心血管疾病是一个很好的预测因子。他汀类药物可以降低心血管疾病风险,这可能会其对肾功能的益处有关。本研究的目的旨在评估阿托伐他汀对肾功能的影响,及其对心血管结局的影响。本研究分析了6个大型阿托伐他汀临床试验的数据,并对30621名患者的血清肌酐倒数的斜率代表肾功能的改变([Mg/DL]-1/y)进行了分析。患者根据治疗方法分成了三类:安慰剂组(n = 10

Diabetes Care:Sotagliflozin对1型糖尿病患者肾功能、白蛋白尿、血压和血细胞比容的影响

由此可见,SOTA与短期和长期肾血流动力学变化相关,与2型糖尿病患者SGLT2i相似。关于SOTA对1型糖尿病患者心肾功能影响进行进一步研究是合理的。

Sci Rep:经历微创肾结石手术患者肾功能变化研究

最近,有研究人员在一个前瞻性和观察性的研究中,调查了微创肾结石手术患者后分离肾功能术后减退的显著预测因子。研究包括了117名连续性患者,他们均经历了逆行肾内手术或者微创的经皮肾镜取石术,且他们的肾结石大于10mm。基于双侧的肾功能的差异,单独肾功能的减退分成3个群组:正常退化(小于10%),中等退化(10-20%)和重度退化(大于20%)。研究发现,共46名患者具有正常的单独肾功能,而71名(60

Crit Care:造影剂对脓毒症相关的急性肾损伤患者肾功能和预后影响

由此可见,单次给予造影剂与脓毒症患者AKI恶化或短期/长期死亡率增加无关。

Hypertension:原发性醛固酮增多症治疗后肾小球滤过率急性下降与肾功能长期减弱的关系

因此,服用MR拮抗剂引起的eGFR急剧下降越小,长期eGFR下降的速率越大。虽然原发性醛固酮增多症特异性治疗引起的eGFR急剧下降有时是一个临床问题,但该研究结果强调了急性下降对长期肾脏转归的有利影响。

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