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JCEM:减肥餐对支链氨基酸和脂肪分布的影响

2020-06-21 MedSci原创 MedSci原创

该研究的结果表明减肥餐诱导的血浆BCAA减少与肝脏和腹部脂肪的减少有关。另外,饮食蛋白质的摄入可能会改变这些关联。

最近的证据已经表明循环支链氨基酸(BCAA)与异位脂肪分布相关。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在探究减肥餐诱导的血浆BCAA改变与对肝脏脂肪和腹部脂肪之间的关系,以及不同饮食潜在的改变效应。

这项研究纳入了预防超重和使用新饮食策略试验的184名参与者,并在2年内对血浆BCAA、肝脏脂肪和腹部脂肪进行了重复测量。该研究的主要观察指标为重复测量的肝脏脂肪、腹部脂肪分布,包括内脏脂肪组织(VAT)、皮下脂肪组织(SAT)和总脂肪组织(TAT)。

在2年中,血浆中总BCAA的减少与肝脏密度的改善(肝脏脂肪的标志;p=0.02)和腹部脂肪(包括VAT、SAT和TAT)的减少均显著相关(所有p<0.05)。此外,研究人员观察到BCAA的减少与胰岛素、HOMA-IR和甘油三酸酯的减少有关,而与体重减轻无关(所有p<0.05)。此外,研究人员发现饮食中的蛋白质摄入量在6个月时显著改变了总血浆BCAA变化与肝密度之间的关系(相互作用p=0.01)。与总BCAA减少或增加较少的参与者相比,总BCAA减少较多的参与者在食用高蛋白饮食时肝脏密度增加更大。

该研究的结果表明减肥餐诱导的血浆BCAA减少与肝脏和腹部脂肪的减少有关。另外,饮食蛋白质的摄入可能会改变这些关联。

原始出处:

Xiang Li,et al.Changes of Branched-Chain Amino Acids and Ectopic Fat in Response to Weight-loss Diets: the POUNDS Lost Trial.JCEM.2020.https://doi.org/10.1210/clinem/dgaa377

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    2021-01-26 smallant2015
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    2020-09-05 achengzhao
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    2020-06-21 CHANGE

    什么时候有懒人用的减肥神药?

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