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Hypertension:线粒体功能异常和活性氧均参与介导妊高症的病理过程

2018-07-21 MedSci MedSci原创

胎盘缺血被认为是子娴前期发展的初始事件。线粒体功能异常会导致产生活性氧(ROS)和氧化应激,线粒体ROS是否在子娴前期病理过程中发挥作用,尚无人对此进行研究。Venkata Ramana Vaka等研究人员在子宫低灌注压(RUPP)的子娴前期大鼠模型中研究胎盘缺血线粒体介导的氧化应激的影响,同时研究线粒体ROS是否在胎盘缺血导致高血压的过程中发挥作用。大鼠孕14天时,予以行RUPP术。孕19天时,

胎盘缺血被认为是子娴前期发展的初始事件。线粒体功能异常会导致产生活性氧(ROS)和氧化应激,线粒体ROS是否在子娴前期病理过程中发挥作用,尚无人对此进行研究。

Venkata Ramana Vaka等研究人员在子宫低灌注压(RUPP)的子娴前期大鼠模型中研究胎盘缺血线粒体介导的氧化应激的影响,同时研究线粒体ROS是否在胎盘缺血导致高血压的过程中发挥作用。

大鼠孕14天时,予以行RUPP术。孕19天时,检测其平均动脉压,并收集正常妊娠和行RUPP术的大鼠的胎盘和肾脏,检测线粒体呼吸、ROS和氧化磷酸化酶活性。与正常孕鼠的线粒体相比,行RUPP术的孕鼠的肾/胎盘综合活性、表达和呼吸率显著降低,线粒体ROS升高。与正常孕鼠(5只)相比,RUPP鼠(6只)的平均动脉压升高(126±4 vs 103±4mmHg;p<0.05),此外,用线粒体特异性抗氧化剂(MitoQ/Mito TEMPO)治疗RUPP鼠(5-10只)可明显降低其血压。以RUPP鼠的血清孵育的内皮细胞的线粒体ROS较正常鼠的血清所孵育的显着升高,而用mito抗氧化剂处理的RUPP鼠来源的血清可减弱上述反应。

线粒体功能受损和血管、胎盘以及肾线粒体ROS均在妊娠高血压和胎盘缺血所导致的胎儿体重减轻中发挥重要作用。

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CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501315, encodeId=8713150131543, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Jul 23 03:35:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333284, encodeId=0adc333284a7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 22 07:21:25 CST 2018, time=2018-07-22, status=1, ipAttribution=)]
    2018-10-16 zxxiang
  5. 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CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501315, encodeId=8713150131543, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Jul 23 03:35:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333284, encodeId=0adc333284a7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 22 07:21:25 CST 2018, time=2018-07-22, status=1, ipAttribution=)]
  6. 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2018, time=2018-07-22, status=1, ipAttribution=)]
  7. 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encodeId=f39420389518d, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sat Jul 28 19:35:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1301380, encodeId=41f31301380cf, content=<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65217, encryptionId=b79c6521eb7, topicName=活性氧)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2b4297, createdName=徐岩, createdTime=Mon Jul 23 03:35:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501315, encodeId=8713150131543, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Mon Jul 23 03:35:00 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333284, encodeId=0adc333284a7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jul 22 07:21:25 CST 2018, time=2018-07-22, status=1, ipAttribution=)]
    2018-07-23 徐岩
  8. 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2018, time=2018-07-22, status=1, ipAttribution=)]
    2018-07-22 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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