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Cancer Cell:新研究发现脂肪细胞为肿瘤供能的机制

2018-04-10 周舟 新华社

美国《癌细胞》杂志9日发表的一项研究解释了脂肪组织如何为肿瘤提供能量。这为医学界研发新的抗癌疗法提供了可能。

美国《癌细胞》杂志9日发表的一项研究解释了脂肪组织如何为肿瘤提供能量。这为医学界研发新的抗癌疗法提供了可能。

美国桑福德-伯纳姆-普雷比斯医学发现研究所和德国慕尼黑工业大学的研究人员通过动物实验发现,脂肪细胞中一种名为p62的蛋白质失活,会抑制一种叫作哺乳动物雷帕霉素靶蛋白的蛋白质,从而促进前列腺肿瘤关闭脂肪组织的耗能过程,吸收脂肪酸和其他营养,加快生长并转移到身体其他部位。

研究人员指出,目前哺乳动物雷帕霉素靶蛋白抑制剂被应用在很多癌症的治疗上,而这项研究正好可以解释这种抑制剂是如何发挥抗癌功效的。

参与研究的桑福德-伯纳姆-普雷比斯医学发现研究所的玛利亚·迪亚兹-梅科表示,癌症不仅是一种基因或细胞疾病,还是一种肿瘤和代谢器官相互交流以不断夺取营养的全身性过程。这项研究将有助医学界发现更好的抗癌疗法。

原始出处:

Jianfeng Huang, Angeles Duran, Miguel Reina-Campos, et.al. Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. Cancer Cell Volume 33, Issue 4, p770–784.e6, 9 April 2018

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    2018-08-30 维他命
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    2018-04-11 wxl882001

    了解一下

    0

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    2018-04-10 三生有幸9135

    学习一下谢谢分享

    0

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