JCO：电话心理咨询可改善宫颈癌患者的生活质量

2015-02-28 Jessie 译 MedSci原创

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宫颈癌存活者在完成治疗后数年，生活质量仍存在不足。近期，加州大学欧文分校的研究者在JCO杂志上报道了他们的一项关于心理社会电话咨询（psychosocial telephone counseling，PTC）干预对宫颈癌存活者生活质量和部分生物学指标影响的研究结果。

该研究运用随机对照的实验设计，招募了204名宫颈癌患者，患者的诊断时间在9个月及以上30个月以内。将这些患者随机分为两组，一组接受PTC干预，另一组接受常规护理。PTC包括为期5周每周一次的电话心理咨询及为期一个月的支持期。分别在基线、开始干预后的4个月和9个月评估患者自我报告的结局变量（焦虑、抑郁、妇科相关的担忧、癌症相关的担忧等），并收集生物样本检测其中的细胞因子水平。主要的分析方法是多变量重复测量方差分析，用来比较不同时间点结局变量的差异及与细胞因子的关系。

患者的平均年龄为43岁，其中40%为西班牙裔，51%为非西班牙裔白人。控制了患者的年龄和基线时的结局变量水平，4个月时接受PTC的患者的抑郁、妇科及癌症相关的担忧较接受常规护理的患者有显著的改善（P＜0.05）。9个月时接受PTC的患者的妇科及癌症相关的担忧仍低于接受常规护理的对照组（P＜0.05）。PTC干预前后生活质量和焦虑水平的变化没有达到统计学意义。细胞因子方面，IL-4，IL-5，IL-10及IL-13降低的患者与升高的患者相比，生活质量显著改善。

结论：本研究证实PTC干预对宫颈癌存活者的情绪、生活质量及妇科和癌症相关的担忧具有改善作用。细胞因子降低与结局变量的改善有关，提示癌症存活者可能存在着与癌症有关的生物行为学通路。

原始出处：

Wenzel L, Osann K, Hsieh S, Tucker JA, Monk BJ, Nelson EL. Psychosocial Telephone Counseling for Survivors of Cervical Cancer: Results of a Randomized Biobehavioral Trial. J Clin Oncol. 2015 Feb 23. pii: JCO.2014.57.4079. [Epub ahead of print]

本文是MedSci编译，欢迎转载，转载请注明出处，非常感谢！

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2021-11-09 湘雅科教

已拜读，受益匪浅。

76 0
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2015-04-22 zxl737

#心理咨询#

67 0
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2015-05-16 ljjj1053

很不错学习了

125 0
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2016-01-06 lizhou0204

#电话心理咨询#

53 0
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2015-11-06 lidong40

#JCO#

54 0
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2015-03-02 一闲

#宫颈#

46 0
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2015-02-28 zhouanxiu

不错，给了一定的课题启发

127 0
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2015-02-28 medcardio

沟通重要！

119 0

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