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PRS:3D打印聚己内酯模具成型的切块软骨显示出软骨细胞的再生潜力

2022-10-24 MedSci原创 MedSci原创

自体软骨移植经常在许多手术中用作支持材料。然而,对使用块状软骨移植物的关注,例如不可预测的吸收量、皮下可见性、皮肤暴露、有限的供体面积、移植物成形中遇到的困难以及由于明显弯曲而需要修正,限制了这些移植

自体软骨移植经常在许多手术中用作支持材料。然而,对使用块状软骨移植物的关注,例如不可预测的吸收量、皮下可见性、皮肤暴露、有限的供体面积、移植物成形中遇到的困难以及由于明显弯曲而需要修正,限制了这些移植物的使用。

使用切块软骨移植物的主要问题与移植物成形中遇到的困难和不可预测的移植物吸收有关。相关研究结果以“Evaluation of Diced Cartilage Grafts Shaped with Three-Dimensionally–Printed Bioresorbable Polycaprolactone Molds”为题,于2022年10月发表在《Plastic & Reconstructive Surgery》杂志。

原始文章

用制作成所需形状和形式的模具来塑造切块软骨移植物(比块状软骨移植物具有更高的生存能力,且并发症发生率更低。该研究旨在评估使用可生物降解的聚己内酯塑造自体切块软骨移植物对移植物持久性和存活力的影响。

图1 聚己内酯模具表征

图2块状软骨移植物、切块软骨移植物和用聚己内酯模具成型的切块软骨移植物

 

结果显示,用三维打印的聚己内酯模具成型的切块软骨显示出软骨细胞的再生潜力、血管化和胶原蛋白的产生增加。使用聚己内酯模具不会导致任何额外的炎症、纤维化或化生骨形成的风险。

图3 软骨细胞的再生能力

 

在这项研究中,已经表明三维打印的聚己内酯模具可以安全地用于成型软骨移植物。由于聚己内酯具有生物相容性和生物可降解性,并具有合适的机械强度和耐久性,因此聚己内酯可能是成形软骨块的理想异体塑料材料。

根据这项研究,借助于以更复杂的方式生产的模具,将有可能生产出可安全用于许多手术的混合移植物。切成丁的软骨移植物可以在聚己内酯模具的帮助下成型,用于需要软骨移植的手术,如隆鼻、鼻重建、耳廓重建和眶底骨折修复。

 

原始文章:

Canli M, Karasoy Yeşilada A, Ulağ S, Dobral A, Yalçin Ö, Gündüz O. Evaluation of Diced Cartilage Grafts Shaped with Three-Dimensionally-Printed Bioresorbable Polycaprolactone Molds. Plast Reconstr Surg. 2022;150(4):800e-809e. doi:10.1097/PRS.0000000000009572

 

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    2022-10-24 delianjihui

    转发学习

    0

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    2022-10-24 delianjihui

    感谢分享

    0

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    2022-10-24 delianjihui

    3D再造,成型意义重大

    0

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    2022-10-24 delianjihui

    学习受益

    0

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    2022-10-24 医鸣惊人

    认真学习了

    0

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