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JACC:血清BNP水平升高与心肌纤维化呈相关性

2017-12-19 MedSci MedSci原创

血清N-末端B型钠尿肽(NT-proBNP)被认为是心肌受到牵拉或者可能的纤维化的血清标志物,然而,其与心肌纤维化的相关性尚缺乏人群研究。本研究的目的旨在评估MESA研究中的心肌纤维化的心脏磁共振(CMR)检查结果与患者血清NT-proBNP水平之间的相关性。本研究共纳入1334名(52%白种人,23%黑种人,11%中国人,14%西班牙裔,其中男性占52%,平均年龄为67.6岁)参与者,并对其NT

血清N-末端B型钠尿肽(NT-proBNP)被认为是心肌受到牵拉或者可能的纤维化的血清标志物,然而,其与心肌纤维化的相关性尚缺乏人群研究。本研究的目的旨在评估MESA研究中的心肌纤维化的心脏磁共振(CMR)检查结果与患者血清NT-proBNP水平之间的相关性。

本研究共纳入1334名(52%白种人,23%黑种人,11%中国人,14%西班牙裔,其中男性占52%,平均年龄为67.6岁)参与者,并对其NT-proBNP水平和心脏磁共振进行了检查。在对所有变量进行调整分析后,发现log NT-proBNP每升高一个SD值(0.44 pg/ml),细胞外体积分数则升高0.62%(p < 0.001),分配系数则升高0.011(p < 0.001),磁共振的原始T1则增加4.7ms(p = 0.001)。若将患有心血管疾病的研究对象排除后,结果仍不变。

研究结果显示,血清N-末端B型钠尿肽的升高与亚临床心肌纤维化呈独立相关性。

原始出处:

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    2018-02-22 hbwxf
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    2018-04-29 okhuali
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    2017-12-21 huiwelcome
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    2017-12-20 天涯183

    非常好的文章.学习了

    0

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    2017-12-20 明崖

    学习了.好文分享

    0

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    2017-12-19 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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