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Hypertension:慢性肾病患儿舒张功能与动态高血压

2021-10-08 MedSci原创 MedSci原创

与单独的诊室血压相比,动态血压可更好地识别伴有亚临床心功能障碍风险的慢性肾病儿童。

舒张功能障碍是慢性肾病患者最早出现的心脏异常之一。

近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在分析儿童慢性肾病(CKiD)队列中786名儿童和青少年(1658人次随访)左心室功能超声心动图标志物,CKiD研究是一项针对慢性肾病儿童的大型前瞻性观察研究。

该研究的主要结局是作为左心室顺应性标志物的早期二尖瓣流入速度与早期二尖瓣环峰值速度(E/e')比值。舒张功能异常定义为E/e′>8.0。

与E/e'正常的儿童相比,E/e'比值异常的儿童年龄更小,估计的肾小球滤过率和血红蛋白水平更低,高血压和左心室肥厚的患病率更高。在调整后的分析中,较高的E/e'比值与动态(持续)高血压独立相关(1.66[95%CI为1.15-2.42])。其他显著的独立预测因素是左心室质量指数Z评分较高、体重指数Z评分增加、血红蛋白较低、血磷水平较高和年龄较小。普通血压与较高的E/e'没有显著相关性。

这些数据表明,与单独的诊室血压相比,动态血压可更好地识别伴有亚临床心功能障碍风险的慢性肾病儿童。

原始出处:

Mark M. Mitsnefes.et al.Diastolic Function and Ambulatory Hypertension in Children With Chronic Kidney Disease.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17449

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    2021-10-09 学医无涯

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