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罗氏的抗病毒药物在PhIII试验中达标

2018-07-17 MedSci MedSci原创

罗氏的抗病毒药物baloxavirmarboxil
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罗氏公司表示，其研发的流感药物baloxavir marboxil已经获得了日本Shionogi的许可，在后期试验中达到了关键目标。来自第三阶段CAPSTONE-2研究的数据，该研究评估了流感并发症高风险人群的抗病毒药物，与安慰剂相比，在改善流感症状的主要终点时表现出更高的疗效。与安慰剂和奥司他韦相比，Baloxavir marboxil在一系列次要终点（包括病毒脱落和降低体内病毒水平）方面也表现



罗氏公司表示，其研发的流感药物baloxavir marboxil已经获得了日本Shionogi的许可，在后期试验中达到了关键目标。

来自第三阶段CAPSTONE-2研究的数据，该研究评估了流感并发症高风险人群的抗病毒药物，与安慰剂相比，在改善流感症状的主要终点时表现出更高的疗效。

与安慰剂和奥司他韦相比，Baloxavir marboxil在一系列次要终点（包括病毒脱落和降低体内病毒水平）方面也表现出卓越的疗效，并且还显着降低了流感相关并发症的发生率。

该公司还表示，值得注意的是，该药物耐受性良好，没有发现任何安全信号。

"Baloxavir marboxil是第一种抗病毒药物，对那些最容易感染流感并发症的人，包括老年人和那些有一定医疗条件的人来说，具有临床意义，"罗氏首席医疗官、全球产品开发主管桑德拉·霍宁(Sandra Horning)说。

"我们计划向医疗保健机构提交第二次三期药物研究的阳性结果，并期待讨论下一步措施，因为目前没有批准专门用于治疗这一高危人群的抗病毒药物。"

结果将在即将举行的医学会议上公布。


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    2018-08-20 wmr111

    #III试验#

    0

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    2018-10-07 juliusluan78

    #III#

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-19 yahu

    #抗病毒#

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-19 yangshch

    #抗病毒药物#

    0

  5. 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    2018-07-19 jihuaijun1112

    学习学习学习

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 kafei

    学习了谢谢

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 zb1235672

    学习了

    0

  8. 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encryptionId=2b00554848e, topicName=抗病毒药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, createdName=yangshch, createdTime=Thu Jul 19 14:31:00 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332580, encodeId=4b8d33258037, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Jul 19 01:18:44 CST 2018, time=2018-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332422, encodeId=11863324222d, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Jul 18 10:19:58 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332405, encodeId=ebcd332405b8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Jul 18 08:55:35 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332398, encodeId=b17d332398b8, content=真正治疗流感的药物学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Wed Jul 18 08:09:17 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332383, encodeId=816333238395, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jul 18 07:23:46 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332348, encodeId=769f33234891, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 liumin1987

    真正治疗流感的药物学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1941636, encodeId=23b0194163694, content=<a href='/topic/show?id=1c6495852f' target=_blank style='color:#2F92EE;'>#III试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9585, encryptionId=1c6495852f, topicName=III试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Mon Aug 20 19:31:00 CST 2018, time=2018-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916026, encodeId=4ec8191602645, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Wed Jul 18 10:19:58 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332405, encodeId=ebcd332405b8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Jul 18 08:55:35 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332398, encodeId=b17d332398b8, content=真正治疗流感的药物学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Wed Jul 18 08:09:17 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332383, encodeId=816333238395, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jul 18 07:23:46 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332348, encodeId=769f33234891, content=学习学习再学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 神功盖世

    阅

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Wed Jul 18 05:24:05 CST 2018, time=2018-07-18, status=1, ipAttribution=)]
    2018-07-18 yjs木玉

    学习学习再学习

    0

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