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Neurology:卒中后抑郁患病率的性别差异

2020-05-01 MedSci原创 MedSci原创

首次卒中后90天抑郁症患病率的性别差异总体上不显著,但因卒中前抑郁症状况而异。需要采取干预措施来解决和预防卒中后抑郁症,特别是那些存在卒中前抑郁症但在卒中发作时未接受过抗抑郁症治疗的个体。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在调查了首次卒中后90天抑郁症患病率的性别差异。

研究人员从科珀斯克里斯蒂项目(2011-2016年)中基于人群的脑卒中监测研究中确定首次卒中患者(n=786)。研究人员通过8项患者健康调查问卷评估了受试者卒中后抑郁症状,并由受试者自我报告卒中前抑郁状态(历史和药物使用情况)。Logistic回归用于评估卒中后性别与抑郁之间的关联,考虑到数据丢失,根据卒中前抑郁状态对影响进行修正。

女性比男性有卒中病史和正在接受药物治疗的可能更大(p<0.001)。男性90天抑郁症的患病率为28.2%(95%置信区间[CI]为23.7%–32.8%),女性为32.7%(95%CI为27.8%–37.5%)。男性和女性卒中后发生抑郁的年龄调整后比值比(OR)为1.34(95%CI为0.97-1.55),并根据社会人口统计学、卒中和卒中前的特征进行了调整后有所减弱。研究人员发现存在卒中前抑郁状态的效应修饰效应(p=0.038)。在卒中时服用抗抑郁药的参与者中,与男性相比,女性在90天时患抑郁的可能性大大降低(OR为0.39;95%CI为0.16-0.96),而在那些有抑郁症病史和无抑郁症病史的患者中,没有发现明显的性别差异。

由此可见,首次卒中后90天抑郁症患病率的性别差异总体上不显著,但因卒中前抑郁症状况而异。需要采取干预措施来解决和预防卒中后抑郁症,特别是那些存在卒中前抑郁症但在卒中发作时未接受过抗抑郁症治疗的个体。

原始出处:

Liming Dong,et al.Sex difference in prevalence of depression after stroke.Neurology.2020.https://doi.org/10.1212/WNL.0000000000009394

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    2020-04-22 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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