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CLIN CANCER RES:头颈部肿瘤中人乳头瘤病毒调节HER3表达

2017-07-04 MedSci MedSci原创

人乳头瘤病毒(HPV)16在头颈部鳞状细胞癌(HNSCC)中具有病因学作用,同时病毒表达的E6和E7癌蛋白是肿瘤生长所必须的物质。HPV+肿瘤患者预后更好,但是目前尚缺乏HPV特异性治疗方式。近期研究发现HPV+肿瘤与HPV-肿瘤受体络氨酸激酶(RTK)不同。HER3就是这些RTK中的一种,HER3在HPV+肿瘤中高表达且与PI3K作用。CLIN CANCER RES近期发表了一篇文章,研究HPV

人乳头瘤病毒(HPV)16在头颈部鳞状细胞癌(HNSCC)中具有病因学作用,同时病毒表达的E6和E7癌蛋白是肿瘤生长所必须的物质。HPV+肿瘤患者预后更好,但是目前尚缺乏HPV特异性治疗方式。近期研究发现HPV+肿瘤与HPV-肿瘤受体络氨酸激酶(RTK)不同。HER3就是这些RTK中的一种,HER3在HPV+肿瘤中高表达且与PI3K作用。CLIN CANCER RES近期发表了一篇文章,研究HPV癌蛋白在调节HER3介导的信号通路中所起到的作用。

作者在细胞系、异种移植模型以及肿瘤组织标本中检测HER3.在HNSCC细胞系中上调E6及E7表达研究HPV与HER3之间的机制联系。使用抗HER3 siRNA以及抗HER3单抗KTN3379在HPV+及HPV- HNSCC模型中研究HER3作用。研究发现在HPV+ HNSCC中HER3过表达,并且与咽癌患者不良预后有关。进一步研究表明E6和E7调节HER3蛋白表达及下游PI3K信号通路。使用siRNA或KTN3379靶向HER3可以显着抑制HPV+细胞系及肿瘤模型肿瘤增殖。

文章最后认为,HPV感染与HNSCC中HER3存在直接联系,为HPV+患者靶向HER3进行治疗提供了理论依据。

原始出处:
Toni M.Brand,Stefan Hartmann,et al.Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer:Implication for Targeted HER3 Therapy in HPV+ Patients.CLIN CANCER RES.June 2017 doi:10.1158/1078-0432.CCR-16-2203

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    2017-07-06 wshxjq
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    2017-07-05 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

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    2017-07-05 大爰

    学习了谢谢分享!!

    0

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图像引导的监督作用与计划颈清扫术治疗相比,对于头部和颈部的鳞状细胞癌患者(晚期淋巴结病阶段N2或N3,主要治疗为放化疗)的效果,仍然是一个有争议的问题。原始出处:Hisham Mehanna,Wai-Lup Wong,Christopher C. McConkey,et al.PET-CT Surveillance versus Neck Dissection in Advanced Head a

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