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UROLOGY：男性睾丸激素水平的动态变化和前列腺癌的风险的纵向研究

2018-02-23 MedSci MedSci原创

prostaticneoplasmsTestosteronehypogonadism
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研究人员使用了来自德国泌尿科诊所的376名性腺机能减退的男性(睾酮12.1 nmol/l或更少)的数据。在第一次发现睾酮低于12.1 nmol/l记录数据，年龄在研究条目中作为次要指标。研究人员得到了3个指标，包括变异系数，相对于平均值最大跌幅和最大跌幅的中位数，并以此来衡量个体中睾丸激素的动态变化模式。

材料和方法

研究人员使用了来自德国泌尿科诊所的376名性腺机能减退的男性(睾酮12.1 nmol/l或更少)的数据。在第一次发现睾酮低于12.1 nmol/l记录数据，年龄在研究条目中作为次要指标。研究人员得到了3个指标，包括变异系数，相对于平均值最大跌幅和最大跌幅的中位数，并以此来衡量个体中睾丸激素的动态变化模式。

结果

研究人员的研究结果表明，在男性体内，睾酮水平低于12.1 nmol/l的人，患前列腺癌的风险更低(HR 0.68， 95% CI 0.57-0.82)。进一步下跌或动态变化的睾丸激素与前列腺癌的风险增加有关(变异系数高和低HR指数只差4.88，95%可信区间1.97 - -12.08，高和低的比率最大跌幅相对于平均HR指数8.45，95%可信区间2.82 - -25.37，高和低的中值最大HR指数下降2.70，95% CI 1.15 - -6.35)。

结论

据研究人员所知，这项研究首次提供了睾丸激素动态模式与前列腺癌发展之间的联系的证据。这可能对前列腺癌的预防有实质性的临床影响。

原始出处：
Xiaohui Xu.et al.Dynamic Patterns of Testosterone Levels in Individuals and Risk of Prostate Cancer among Hypogonadal Men： A Longitudinal Study.UROLOGY.2018.

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    2018-12-16 仁医06

    #动态变化#

    0

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    2018-03-04 经常头晕

    #激素水平#

    0

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    2019-02-06 lfyang

    #睾丸激素#

    0

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    2018-06-16 jj000012

    #纵向研究#

    0

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    2018-02-25 zhangph

    #睾丸#

    0

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