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Clin Gastroenterology H:胃癌发病率不同的地区会影响移入人口的胃癌发病率

2020-01-22 不详 MedSci原创

胃癌是是癌症死亡的主要原因。目前,移民人口对胃癌风险的影响尚不明确,因此,本项研究进行了系统的回顾和荟萃分析,以确定从高发地区到低发地区的移民中胃癌发生的风险。

背景与目标
癌是是癌症死亡的主要原因。目前,移民人口对癌风险的影响尚不明确,因此,本项研究进行了系统的回顾和荟萃分析,以确定从高发地区到低发地区的移民中胃癌发生的风险。

方法
研究人员从1980年1月至2019年1月在MEDLINE和EMBASE数据库中进行了研究,这些文章的研究人群均为胃癌高发地区的移民,提供了足够的数据来计算胃癌的发病率和胃癌,相关死亡率。

结果
研究人员确定了38项符合纳入标准的队列研究。所有针对21个不同人群的13项研究均报告说,第一代外来移民的胃癌标准发病率(SIR)显着增加(男性SIR范围为1.24–4.50,女性SIR范围为1.27–5.05)。患有所有类型胃癌的移民的合并SIR男性为1.66(95%CI,1.52-1.80),女性为1.83(95%CI,1.69-1.98)。来自2个高发人群的9项研究(前苏联和日本)报告说,移居到低发病率地区的第一代移民(前苏联移民,男性为1.44–1.91,而前苏联为1.40–1.4)。

结论
本项研究显示从胃癌高发地区到胃癌低发地区的移民维持较高的胃癌风险和相关死亡率。

原始出处:

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    2020-06-29 许安
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Clinical and Translational Gastro: 胃中非幽门螺杆菌产生的脂多糖会刺激胃上皮细胞中白细胞介素-8的产生

慢性幽门螺杆菌感染会导致胃酸分泌受损,并导致胃内非幽门螺杆菌胃细菌(NHGB)过度生长,从而引起不良后果。因此,本项研究旨在探究二者之间的关系。

J Gastroenterology: 根除幽门螺杆菌后第二个十年的胃癌的发生风险

根除幽门螺杆菌可降低患胃癌的风险。在这项研究中,研究人员调查了根除幽门螺杆菌10年后胃癌的发生风险。

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