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Br J Cancer:HOX基因:肾上腺皮质癌的潜在治疗靶标

2020-11-24 xiaozeng MedSci原创

肾上腺皮质肿瘤是一种相对常见的疾病,患病率为1-10%。其中大多数为良性腺瘤,但在极少数情况下(每年每百万最多2例)会发展为肾上腺皮质癌(ACC),这是一种侵袭性疾病,其5年生存率很低。

肾上腺皮质肿瘤是一种相对常见的疾病,患病率为1-10%。其中大多数为良性腺瘤,但在极少数情况下(每年每百万最多2例)会发展为肾上腺皮质癌(ACC),这是一种侵袭性疾病,其5年生存率很低。

当前ACC的治疗方法包括非转移性疾病的手术和米托坦(mitotane)疗法,然而在晚期患者中疗效有限。因此,了解驱动ACC发生发展的信号通路对于开发更有效的治疗方法和预测个体结局至关重要。


该研究旨在探究转录因子HOXB9和其他HOX因子在ACC发生发展中的作用及对治疗的贡献。

HOXB9与侵袭性ACC相关

研究人员使用转基因小鼠模型分析Hoxb9在肾上腺肿瘤发生发展中的作用。通过分析患者的转录组数据,了解HOX基因的表达情况及其与疾病的关系。并通过各种肾上腺皮质模型的药物反应研究,建立新的治疗选择。


人类ACC数据集分析显示,HOXB9和其他HOX因子的高表达水平与患者的不良预后相关。研究人员发现,在Ctnnb1激活的小鼠肾上腺皮质中的过表达Hoxb9能够导致更大的肾上腺肿瘤。该表型优先表现于雄性小鼠中,其特征为细胞增殖的增多,细胞周期相关基因(包括Ccne1)的表达水平升高。进一步的研究显示,肾上腺肿瘤细胞的存活依赖于HOX功能,且对特定的肽抑制剂敏感。

ACC细胞对HOX-PBX功能抑制敏感

综上,该研究结果表明,Hoxb9能够以性别依赖性的方式促进肾上腺肿瘤的发生发展,HOX因子被鉴定为潜在的药物靶标,或可成为ACC的新型治疗方法。


原始出处:

Francis, J.C., Gardiner, J.R., Renaud, Y. et al. HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours. Br J Cancer (20 November 2020).

 

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    2021-04-30 MedSciZeng

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    2020-11-26 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1909466, encodeId=f129190946602, content=<a href='/topic/show?id=be1864e205a' target=_blank style='color:#2F92EE;'>#治疗靶标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64720, encryptionId=be1864e205a, topicName=治疗靶标)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a885259, createdName=yourmama, createdTime=Sat May 08 00:55:01 CST 2021, time=2021-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961872, encodeId=8a189618e2d2, content=<a href='/topic/show?id=d12d1042620a' target=_blank style='color:#2F92EE;'>#Br J Cancer#</a>点击查看更多相关话题,或评论点击插入您喜欢的话题, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104262, encryptionId=d12d1042620a, topicName=Br J Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:22:30 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895216, encodeId=284018952165b, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, createdTime=Wed Jan 06 06:55:01 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670344, encodeId=e41f16e034485, content=<a href='/topic/show?id=81c08243e51' target=_blank style='color:#2F92EE;'>#肾上腺皮质癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82437, encryptionId=81c08243e51, topicName=肾上腺皮质癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d27026610809, createdName=liuquan, createdTime=Mon Sep 06 14:55:01 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1352875, encodeId=994e13528e58e, content=<a href='/topic/show?id=827d9996311' target=_blank style='color:#2F92EE;'>#靶标#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99963, encryptionId=827d9996311, topicName=靶标)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 26 03:55:01 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901766, encodeId=89b8901e66ab, content=oxb9能够以性别依赖性的方式促进肾上腺肿瘤的发生发展,HOX因子被鉴定为潜在的药物靶标, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210325/2d9c955949df4b349a439f1a6773499e/b39f4845e869489d95bc545c79cf60fa.jpg, createdBy=303f5433779, createdName=Oranhyg, createdTime=Tue Nov 24 13:41:51 CST 2020, time=2020-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901756, encodeId=2195901e5639, content=肾上腺皮质肿瘤是一种相对常见的疾病,患病率为1-10%, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Tue Nov 24 13:27:22 CST 2020, time=2020-11-24, status=1, ipAttribution=)]
    2020-11-24 Oranhyg

    oxb9能够以性别依赖性的方式促进肾上腺肿瘤的发生发展,HOX因子被鉴定为潜在的药物靶标

    0

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    2020-11-24 Jessie Zhang

    肾上腺皮质肿瘤是一种相对常见的疾病,患病率为1-10%

    0

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