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J Hepatology:哺乳期的延长与女性非酒精性脂肪性肝病患病率降低有关

2018-12-17 MedSci MedSci原创

哺乳期的女性降血糖和甘油三酯会明显下降,并且胰岛素敏感性会增加。研究人员假设较长的哺乳期与较低的非酒精性脂肪性肝病(NAFLD)患病率相关,并对此进行了相关研究

背景与目的
哺乳期的女性降血糖和甘油三酯会明显下降,并且胰岛素敏感性会增加。研究人员假设较长的哺乳期与较低的非酒精性脂肪性肝病(NAFLD)患病率相关,并对此进行了相关研究

方法
研究人员对所有符合条件的患者(n = 844)进行了肝脏脂肪变性的CT量化测量,对所有出生时的哺乳持续时间进行计算,并通过CT图像的中心回顾评估NAFLD的发生率。使用混杂变量进行未调整和多变量逻辑回归分析。

结果
本项研究共纳入了844名女性(48%黑人,52%白人,平均年龄49岁),32%的患者的哺乳期为0至1个月,25%的患者的哺乳期为1至6个月,43%的患者的哺乳期超过6个月,而最后有54(6%)名患者出现了NAFLD。在未经调整的逻辑回归中,较长的泌乳持续时间与NAFLD呈负相关关系。对于报告超过6个月的哺乳期妇女与报告0-1个月的妇女相比,NAFLD 明显降低(OR=0.4895%CI 0.25-0.94; p= 0.03),并且在调整混杂因素后仍保持关联(调整后的比值比为0.46; 95%CI 0.22-0.97; p= 0.04)。

结论
哺乳期较长,特别是超过6个月,与中年发生NAFLD的可能性较低相关。

原始出处:

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    2019-07-28 qjddjq
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    2018-12-19 gwc384
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