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Nat Commun:PTEN-ARID4B-PI3K途径鉴定了PTEN缺陷前列腺癌对ARID4B的依赖性

2019-10-06 AlexYang MedSci原创

在前列腺癌中,PTEN经常发生变异。PTEN的肿瘤抑制子功能归结于其脂肪磷酸化活性且能够拮抗PI3K的作用。最近,有研究人员报道了PTEN-ARID4B-PI3K途径,其中PTEN能够抑制ARID4B的表达,而ARID4B是PI3K亚单元基因PIK3CA和PIK3R2的转录激活因子,且亚单元基因PIK3CA和PIK3R2对PI3K/AKT途径的激活是非常关键的。ARID4B和组蛋白H1结合到PIK

在前列腺癌中,PTEN经常发生变异。PTEN的肿瘤抑制子功能归结于其脂肪磷酸化活性且能够拮抗PI3K的作用。

最近,有研究人员报道了PTEN-ARID4B-PI3K途径,其中PTEN能够抑制ARID4B的表达,而ARID4B是PI3K亚单元基因PIK3CA和PIK3R2的转录激活因子,且亚单元基因PIK3CA和PIK3R2对PI3K/AKT途径的激活是非常关键的。ARID4B和组蛋白H1结合到PIK3CA和PIK3R2的启动子能够调控染色质凝聚,表明了ARID4B能够激活这些启动子的机制。功能分析阐释了当PTEN缺失时,ARID4B对前列腺的致瘤作用是需要的。另外,PTEN/ARID4B/PI3K3CA的生物学意义进一步表现在能够增强患者前列腺癌复发预测的能力。

最后,研究人员指出,他们鉴定了ARID4B是PTEN-PI3K途径中的主调控因子,因此为携带PTEN变异的前列腺提供了新的治疗靶标。

原始出处:

Ray-Chang Wu, In-Chi Young, Yu-Fang Chen et al. Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer. Nat Commun. 24 Sep 2019

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    2020-01-05 liuli5079
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    2019-10-07 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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