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Nature:工业化时代人类肠道微生物与古人大不相同

2021-05-19 MedSci原创 MedSci原创

古粪中的微生物的组成和功能与现代粪便中的微生物相比有显著差异。工业化微生物群落中黏液降解物种和基因的患病率高于古代和非工业化微生物群落,这可能是由西方饮食驱动的

居住在人体肠道内的微生物细胞,统称为肠道微生物群,对我们的新陈代谢和免疫系统生物学有关键影响。许多微生物是一代代传下来的。然而,肠道微生物群(通过分析粪便中的微生物DNA来追踪)可能在某些事件发生后的几天至几个月内彻底改变,比如移民到另一个国家或抗生素治疗。确定哪些微生物曾经是我们进化历史的一部分,但后来消失了,这可能为理解微生物和人类健康之间的关系提供了一个关键。 Wibowo等人在Nature杂志上撰文,通过利用微生物“时间机器”-古粪来解决这个问题。通过对1000 - 2000年前的人类粪便样本进行DNA测序,这项研究为了解工业化之前的肠道微生物提供了有价值的见解。 古粪样本的微生物门、科和种组成与现代非工业个体的肠道微生物群落相似   人类的微生物群是我们的生物学中具有可塑性的组成部分,它能适应特定的环境,例如显示出与食物供应相对应的季节性变化。虽然这种延展性为治疗与微生物群有关的人类疾病提供了一个潜在的途径,但它也是一个弱点。工业化生活的许多方面,如抗生素的使用和缺乏纤维的西方饮食,对肠道微生物有负面影响。 哪些来自工业化前微生物群的核心微生物和微生物功能随着社会工

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    2022-03-31 liye789132251
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    2021-06-09 ms1000000626849540

    感谢分享

    0

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    2021-05-20 神盾医疗局局长Jack

    有趣

    0

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