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Endocrine:PTH1-34加MK-4联合治疗可在骨质减少的情况下加速颅骨骨缺损中的骨形成和血管生成

2018-10-13 MedSci MedSci原创

本研究旨在评估人甲状旁腺激素(1-34)(PTH1-34; PTH)和甲基萘醌-4(MK-4)联合对骨质减少大鼠颅骨缺损修复的影响。 对14周龄的老年鼠进行开颅手术以建立通过长期低蛋白饮食喂养的骨质减少的动物模型。之后,建立临界颅骨缺损模型,将所有大鼠随机分为4组:假手术组,MK-4组,PTH组和PTH + MK-4组。动物接受MK-4(30 mg/kg/天),PTH1-34(60μg/kg

本研究旨在评估人甲状旁腺激素(1-34)(PTH1-34; PTH)和甲基萘醌-4(MK-4)联合对骨质减少大鼠颅骨缺损修复的影响。

对14周龄的老年鼠进行开颅手术以建立通过长期低蛋白饮食喂养的骨质减少的动物模型。之后,建立临界颅骨缺损模型,将所有大鼠随机分为4组:假手术组,MK-4组,PTH组和PTH + MK-4组。动物接受MK-4(30 mg/kg/天),PTH1-34(60μg/kg,一周三次)或PTH1-34(60μg/kg,一周三次)加MK-4( 30 mg/kg/天),分别为8周。血清γ-羧化骨钙蛋白(Gla-OC)水平,组织学免疫荧光标记用于评估颅骨骨缺损中的骨形成和矿化。此外,Microfil灌注,免疫组化和微CT表明颅骨骨愈合过程中血管生成和骨形成增强。

结果显示,与假手术组相比,PTH1-34或MK-4治疗促进颅骨骨缺损中的骨形成和血管形成。此外,与单一疗法相比,PTH1-34和MK-4的联合治疗增加了血清Gla-OC水平,改善了血管数量和血管密度,并增强了骨质减少患者颅骨缺损中的骨形成。

总之,本研究表明PTH1-34加MK-4联合治疗可在骨质减少的情况下加速颅骨骨缺损中的骨形成和血管生成。

原始出处:

Weng SJ, Xie ZJ, et al., Effects of combined menaquinone-4 and PTH1-34 treatment on osetogenesis and angiogenesis in calvarial defect in osteopenic rats. Endocrine. 2018 Sep 22. doi: 10.1007/s12020-018-1761-7.

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    2019-04-05 lujian
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    2018-10-15 lfcmxl
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    2018-10-15 Eleven17
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