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Stroke:COVID-19住院患者缺血性卒中的风险、临床过程和结局

2021-11-06 网络 网络

COVID-19住院患者急性缺血性卒中的累积发生率约为2%,在重症监护病房接受治疗的患者风险更高。大多数卒中患者的预后不佳。缺血性卒中与肺栓塞之间的关联值得进一步研究。

2019冠状病毒病(COVID-19)患者缺血性卒中的频率在当前文献中各不相同,危险因素也尚未明确。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员评估了住院COVID-19患者急性缺血性卒中的发生率、危险因素和结局。

研究人员纳入了2020年3月1日至8月1日期间在参与国际CAPACITY-COVID登记的16家荷兰医院接受实验室检查确诊的SARS-CoV-2(严重急性呼吸系统综合症冠状病毒2)感染患者。研究人员筛查了发生急性缺血性脑卒中的患者,并计算了缺血性卒中的累积发病率,以及比较了缺血性卒中患者和非缺血性卒中患者的危险因素、心血管并发症和院内死亡率。

研究人员纳入了2147名COVID-19患者,其中586名(27.3%)患者需要在重症监护病房接受治疗。38名(1.8%)患者伴有缺血性卒中。卒中患者年龄较大,但在性别或心血管危险因素方面没有差异。从COVID-19症状出现到卒中诊断之间的中位时间为2周。在重症监护病房接受治疗的患者缺血性卒中发生率更高(16/586;2.7%,与非重症监护病房相比,22/1561;1.4%;P=0.039)。肺栓塞在伴有卒中患者(8/38;21.1%)中更常见,相比于不伴有卒中的患者(160/2109;7.6%;调整后的风险比为2.08[95%CI为1.52–2.84])。27名(71.1%)缺血性卒中患者在入院期间死亡或在出院时伴有功能依赖。与无卒中患者相比,缺血性卒中患者的院内死亡率风险更高(调整后的风险比为1.56[95%CI为1.13-2.15])。

在这项多中心队列研究中,COVID-19住院患者急性缺血性卒中的累积发生率约为2%,在重症监护病房接受治疗的患者风险更高。大多数卒中患者的预后不佳。缺血性卒中与肺栓塞之间的关联值得进一步研究。

原始出处:

Wouter M. Sluis.et al.Risk, Clinical Course, and Outcome of Ischemic Stroke in Patients Hospitalized With COVID-19: A Multicenter Cohort Study.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.034787

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    2021-11-06 ms1000002136354097

    住院患者大多数缺血性卒中预后不良

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1893442, encodeId=38081893442b6, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Nov 16 00:36:58 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806473, encodeId=e0ac18064e332, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Mon Feb 21 16:36:58 CST 2022, time=2022-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067559, encodeId=f36a106e559eb, content=住院患者大多数缺血性卒中预后不良, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1e05489924, createdName=ms1000002136354097, createdTime=Sat Nov 06 12:48:29 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067529, encodeId=b2b8106e529a8, content=很详细的讲解,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65aa5643711, createdName=小白努力长高高, createdTime=Sat Nov 06 11:33:46 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067493, encodeId=cb23106e493bf, content=存者将面临晚期治疗相关毒性,包括, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Sat Nov 06 10:07:16 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2021-11-06 小白努力长高高

    很详细的讲解,谢谢

    0

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    2021-11-06 查查佳佳

    存者将面临晚期治疗相关毒性,包括

    0

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