Atherosclerosis：麝香保心丸通过上调20-HETE，起到保护心脏的作用

2017-06-27 xiaoxiao MedSci原创

缺血性心脏病治疗的关键策略是血管新生，而麝香保心丸是中医治疗缺血性心脏病时广泛使用的一种中成药。来自广州中山大学的研究人员探讨了麝香保心丸对大鼠心肌梗死模型的血管新生（MI）的影响及其分子作用机制。其研究内容主要如下：以SD大鼠设计了左冠状动脉前降支闭塞的心肌梗死模型。心肌梗死大鼠随机分组，分别使用蒸馏水、麝香保心丸、或麝香保心丸+ HET0016（一种选择性阻断20-羟-二十烷四烯酸[20-HE

缺血性心脏病治疗的关键策略是血管新生，而麝香保心丸是中医治疗缺血性心脏病时广泛使用的一种中成药。来自广州中山大学的研究人员探讨了麝香保心丸对大鼠心肌梗死模型的血管新生（MI）的影响及其分子作用机制。其研究内容主要如下：

以SD大鼠设计了左冠状动脉前降支闭塞的心肌梗死模型。心肌梗死大鼠随机分组，分别使用蒸馏水、麝香保心丸、或麝香保心丸+ HET0016（一种选择性阻断20-羟-二十烷四烯酸[20-HETE]的合成的药物，10mg/kg/天）治疗。以假手术组大鼠作为对照组。

研究人员发现使用麝香保心丸治疗能升高心肌梗死大鼠血清20-HETE的水平，而HET0016可以抑制血清20-HETE水平升高。在心梗大鼠中，麝香保心丸显示了其心脏保护作用，包括改善心脏功能、减少梗死面积、促进梗死区血管新生。麝香保心丸的保护作用是通过部分抑制HET0016产生的。此外，基于免疫组织化学分析，在心梗大鼠的梗死及周围区域，麝香保心丸能提高循环血内皮祖细胞（EPC）的数量和血管内皮生长因子（VEGF）的表达，而HET0016则部分抑制。

麝香保心丸可能参与了心梗大鼠的部分血管新生。麝香保心丸的保护机制可能是通过上调20-HETE，进而促进EPC活性和VEGF表达。

原始出处：

Huang F, Liu Y,et al.Shexiang Baoxin pills promotes angiogenesis in myocardial infarction rats via up-regulation of 20-HETE-mediated endothelial progenitor cells mobilization.Atherosclerosis. 2017 Jun 7;263:184-191. doi: 10.1016/j.atherosclerosis.2017.06.012. [Epub ahead of print]

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2017-10-20 12498b37m72暂无昵称

#Sclerosis#

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2017-07-11 luwei11

#麝香保心丸#

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2017-06-29 lsndxfj

#ROS#

76 0
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2017-06-29 一个字-牛

学习了谢谢分享

127 0
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2017-06-28 zwjnj2

好好好中医药的研究

119 0
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2017-06-28 午后阳光

谢谢分享

102 0
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likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Wed Jun 28 05:46:07 CST 2017, time=2017-06-28, status=1, ipAttribution=)]
2017-06-28 Jackie Li

学习

122 0
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2017-06-28 ren1mw

学习一下吧！学习一下了

117 0
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2017-06-28 刘煜

学习了谢谢分享

75 0
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2017-06-28 189****1577

值得推荐一下

90 0