Baidu
map

一文打尽单纯疱疹病毒(HSV-1/HSV-2)的诊疗

2021-11-05 好医师 好医师

单纯疱疹病毒(HSV)是一种嗜神经性的双链DNA包膜病毒,大量生存于自然界, 可侵入人体和动物体发生感染, 病毒通常经由黏膜、皮肤、神经组织等感染机体而致相关的病变。

单纯疱疹病毒(HSV)是一种嗜神经性的双链DNA包膜病毒,大量生存于自然界, 可侵入人体和动物体发生感染, 病毒通常经由黏膜、皮肤、神经组织等感染机体而致相关的病变。

HSV有HSV-1和HSV-2两种血亚型,HSV-1型和HSV-2型在人群中的血清流行率分别为68%和22%。HSV-1型是世界上流行最广的病毒性感染之一,成年人血清中阳性率高达85%以上,某些国家和地区甚至达到100%,据有关统计资料显示,生殖器疱疹的病原体90%为HSV-2型,仅10%为HSV-1型。据估计全世界有20%人为HSV-2型阳性,并且发病人数以约25%的比例逐年增加。

图片

                    

1.生物学特点

HSV是由被膜、衣壳、核心、囊膜组成的圆形病毒,双链线性的DNA结构纤丝成卷缠绕。HSV-1基因组长度125~240kb,HSV-2的基因组长度在154kb左右,两型核酸序列同源性高达50%。HSV有12种已命名的特异性抗原糖蛋白,是细胞免疫和体液免疫的主要靶标,也是预防和治疗HSV感染的亚单位疫苗或DNA 疫苗的候选基因。

2.感染特点

HSV-1不仅可引起原发感染,而且可造成潜伏感染和再发。原发感染最常引起口咽部疱疹、疱疹性角膜结膜炎、脑炎和皮肤疱疹性湿疹等。感染后病毒可长期潜伏于机体内引起潜伏感染,期间疱疹病毒的结构与功能都不会遭到损坏与影响,并且这时病毒基因转录和表达有关的所有调节均为停滞状况,这期间不存在全面的基因组复制,可存有少量的局部基因转录,潜伏部位为三叉神经节和颈上神经节。潜伏的病毒可被激活,转为增殖性感染,病毒沿感觉神经纤维轴索下行返回末梢,在局部上皮细胞内增殖,引起局部复发性疱疹。
HSV-2潜伏部位为骶神经节。受刺激后潜伏病毒可被激活 ,引起复发感染。

3.临床表现

单纯疱疹病毒感染可引起口、唇或生殖器的皮肤或黏膜上出现典型的集簇性水疱、脓疱、溃疡、结痂,或出现尿道、宫颈炎,也可表现为非特异性红斑、丘疹、裂隙、硬结或疖肿,同时会出现毛囊炎与皮肤擦破等不易识破或是不典型皮损。同时伴有发热、头痛、乏力等全身症状,亦可能有腹股沟淋巴结常肿大及疼痛等体征。临床病症主要包括:龈口炎、角膜结膜炎、脑炎以及生殖系统感染和新生儿的感染。一旦出现感染,会出现异常或是轻微的症状,口腔中第一次发作时,会引发无菌性的脑膜炎。
HSV-1型主要引发躯体腰以上部位皮肤粘膜和中枢神经系统的感染,一般通过口腔及污染的手及飞沫感染,感染多见于儿童,常引起口腔齿龈和口腔炎,多为隐性感染;HSV-2型侵及躯体腰以下部位,多通过性活动传播,主要是生殖器部位皮肤粘膜及新生儿感染,引起生殖器疱疹,幼儿多见龈口炎,儿童多见疱疹唇炎及角膜炎,而生殖道疱疹则青壮年为多,但近些年来有研究表明, 引发生殖器疱疹的病原体中, HSV-1与HSV-2都存在重要作用。

4.治疗原则

对患者的心理负担进行缓解,降低复发率与减轻症状疗法涉及健康宣教、抗病毒、免疫与局部的治疗等。目前,主要治疗的方法为系统的抗病毒,泛昔洛韦、伐昔洛韦以及阿昔洛韦属于常用药物。在治疗单纯疱疹时,可以缓解症状与改善预后,主要包含采取3%的硼酸溶液与生理盐水进行清洗,没有显著的渗出情况,可以采取1%的昔洛韦乳膏与3%的阿昔洛韦乳膏。现有研究表明中药,如黄柏、黄芩苷、玉竹静点或在皮损处湿敷对患者预后也有一定帮助。黄柏主要作用是杀菌止痒以及清热解毒等,相关药理研究中显示还存在抑菌与抗菌作用。黄柏液属于中药的提取物,没有乙醇,不会刺激到皮肤组织,对于上皮细胞爬行比较有利,能够促使创面尽快愈合。并且与免疫治疗联合,对于单纯疱疹治疗效果显著,比较常用免疫调节的药剂包含转移因子与干扰素。同时需要对患者实施心理干预健康教育,经健康宣教让患者维持节律生活的习惯,经心理干预与体育锻炼,能够改善患者负性心理,同样重要。

5.病毒疫苗研究现状

接种疫苗仍是预防病毒感染的理想方法。接种的疫苗可以将HSV-2抗感染的免疫作用充分发挥出来,对体中体液免疫与细胞免疫的功能进行调动,将体内 HSV 感染清除。现阶段,有效的预防性疫苗尚未达到临床试验的严格要求。开发疫苗的尝试主要集中于 HSV-2 作为靶抗原进入所必需的糖蛋白,并且在自然感染期间主要针对中和抗体应答。

6.检测方法

(1)抗体检测:HSV抗体检测( IgM ) 仍是临床上最常用来检测 HSV 感染的手段。初次被HSV感染,5周左右抗HSV抗体会达到高峰,并维持平稳,初期产生的HSV的IgM抗体能保持7周左右。曾感染而拥有抗体者,再次感染或复发时, 抗体浓度无显著变化,并且不产生IgM抗体。

(2)PCR 检测:病毒核酸检测的敏感性较细胞培养高 ,已初步在临床病毒检验工作中显示出了较大的优越性。样本类型:女性宫颈分泌物/男性尿道分泌物。

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (10)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2021-11-29 ms2000001015681385

    鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。

    1

    展开1条回复
  2. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2022-12-27 ms6000001411380643 来自广东省

    希望国家重视!单纯疱疹要害死人,加快根治药物研究

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2021-11-10 gracezdd
  4. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2022-01-17 ms6000001000136144

    疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1075187, encodeId=e12110e5187e6, content=鼻子上发水泡的三四天前两条膝盖酸疼,胸口长了个大水痘,没在意,发前一天,肩周开始疼,后背也隐隐疼,开始头晕头疼有点发烧,感觉思维不清晰,浑身痒了一天,开始浑身疼,犯呕心,下午鼻子上的水泡发出来了,我意识到是疱疹,就赶紧吃阿昔洛韦,今天是吃药第三天,症状全都退去了,就胳膊还是有点痒,主要是头不疼了思维也清晰了,我想如果我不吃药就这症状铁定是脑炎没跑了。这病什么时候能根治,记忆力减退严重。, beContent=null, objectType=article, channel=null, level=null, likeNumber=265, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc345501592, createdName=ms2000001015681385, createdTime=Mon Nov 29 20:41:34 CST 2021, time=2021-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2107652, encodeId=0d7c210e65270, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=543, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:37:47 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1941651, encodeId=d82a19416518e, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Nov 10 12:59:07 CST 2021, time=2021-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987771, encodeId=4b55198e771eb, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Sun Mar 06 10:59:07 CST 2022, time=2022-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1185231, encodeId=76b81185231dc, content=疫苗开发进度查询 https://trello.com/b/MZFzqFvH/vaccine-advocate , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28b96458995, createdName=ms6000001000136144, createdTime=Mon Jan 17 16:36:44 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720705, encodeId=e9081e20705ab, content=<a href='/topic/show?id=e9d791e02a' target=_blank style='color:#2F92EE;'>#HSV-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9170, encryptionId=e9d791e02a, topicName=HSV-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28dd32934037, createdName=bnjfx@137.com, createdTime=Mon Jun 20 08:59:07 CST 2022, time=2022-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490583, encodeId=e3121490583c1, content=<a href='/topic/show?id=7b98362e8f8' target=_blank style='color:#2F92EE;'>#单纯疱疹病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36278, encryptionId=7b98362e8f8, topicName=单纯疱疹病毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a61f8789613, createdName=cnxcy, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580482, encodeId=9af21580482d7, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2dcf16628144, createdName=ms2694732865965676, createdTime=Sun Nov 07 08:59:07 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1067472, encodeId=0298106e472ed, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644b2182796, createdName=1207866fm50(暂无昵称), createdTime=Sat Nov 06 08:16:58 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2021-11-06 1207866fm50(暂无昵称)

    谢谢分享

    0

相关资讯

ACOG指南:妊娠期疱疹的管理

妊娠期感染生殖器单纯疱疹病毒(HSV)会对胎儿及新生儿 造成危胁。在美国20%的妇女感染生殖器疱疹,因为许多生育年龄的女性已经被感染或者 正在受到HSV的感染,病毒通过母体传播给胎儿及新生儿的风险是健康领域倍受关注的课 题。这篇文章的主旨即为孕产妇及新生儿感染疱疹病毒提供纲领性建议。包括传播的风 险以及基于科学的基础研究而得来的处理指南,还有许多来自临床专家的共识。

Ann Rheum Dis:系统性红斑狼疮患者严重单纯疱疹病毒的感染风险

SLE患者发生严重HSV感染的风险较高,其相关危险因素包括年龄大于18岁、有HSV粘膜皮肤感染病史、近期接受类固醇冲击治疗和每日口服泼尼松龙剂量超过7.5mg。

Baidu
map
Baidu
map
Baidu
map