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综述:锰与肿瘤——从MnSOD到天然免疫复苏剂,能极大增强肿瘤免疫反应

2021-08-22 MedSci原创 MedSci原创

在癌症的治疗研究领域,医学界和科研人员从未放弃过新的治疗手段。肿瘤免疫治疗问世以后,让大量的患者得到有效的治疗。然而,面临的现实难题是,仅有少部分患者可以从肿瘤免疫中得到获益。因此,大家在不断尝试不同

在癌症的治疗研究领域,医学界和科研人员从未放弃过新的治疗手段。肿瘤免疫治疗问世以后,让大量的患者得到有效的治疗。然而,面临的现实难题是,仅有少部分患者可以从肿瘤免疫中得到获益。因此,大家在不断尝试不同的组合方法,让更多的患者获益,例如化疗+免疫治疗,放疗+免疫治疗,抗血管新生治疗+免疫治疗,双重或三重免疫治疗组合等,均取得不同程度的进展。国内的相关科研团队,发现了锰离子在肿瘤免疫治疗领域的关键作用,令人惊喜。梅斯医学小编帮助大家汇总一下,与大家分享。 2018年4月17日,国际免疫学著名学术期刊Immunity上报道北京大学生命科学学院蒋争凡研究组在天然免疫领域的最新研究成果——Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-stranded DNA and Is Required for the Host Defense against DNA Viruses。天然免疫是宿主抵抗病原微生物入侵的第一道防线。在抗病毒天然免疫反应中,机体通过cGAS-STING信号通路感受DNA病毒的入侵,

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    2021-08-22 病毒猎手

    #锰##肿瘤#,锰是一个极有潜力的治疗药物,便宜方便使用,建议大规模推广。不过从这篇文章来看,单纯MnO2或MnCl2效果似乎一般,还应该用一些#纳米#技术进行改进,才可能取得更好的效果。另外,锰对#肿瘤免疫治疗#方面,应该是一个重要的助手,也许将来有一天,锰,#地西他滨#,甚至#沙度利胺#这一类免疫调节剂联合或序贯使用,或根据免疫微环境特征,有针对性选择,可能更能诱导更强的免疫治疗效果

    1

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1010352, encodeId=694d1010352b1, content=<a href='/topic/show?id=9b3996e6940' target=_blank style='color:#2F92EE;'>#锰#</a>与<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>,锰是一个极有潜力的治疗药物,便宜方便使用,建议大规模推广。不过从这篇文章来看,单纯MnO2或MnCl2效果似乎一般,还应该用一些<a href='/topic/show?id=28a6e73517e' target=_blank style='color:#2F92EE;'>#纳米#</a>技术进行改进,才可能取得更好的效果。另外,锰对<a href='/topic/show?id=a07f82814ec' target=_blank style='color:#2F92EE;'>#肿瘤免疫治疗#</a>方面,应该是一个重要的助手,也许将来有一天,锰,<a href='/topic/show?id=2d4c4140296' target=_blank style='color:#2F92EE;'>#地西他滨#</a>,甚至<a href='/topic/show?id=564f10439123' target=_blank style='color:#2F92EE;'>#沙度利胺#</a>这一类免疫调节剂联合或序贯使用,或根据免疫微环境特征,有针对性选择,可能更能诱导更强的免疫治疗效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=252, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=96769, encryptionId=9b3996e6940, topicName=锰), TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤), TopicDto(id=77351, encryptionId=28a6e73517e, topicName=纳米), TopicDto(id=82814, encryptionId=a07f82814ec, topicName=肿瘤免疫治疗), TopicDto(id=41402, encryptionId=2d4c4140296, topicName=地西他滨), TopicDto(id=104391, encryptionId=564f10439123, topicName=沙度利胺)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Aug 22 17:49:27 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280247, encodeId=803a128024eb3, content=<a href='/topic/show?id=2bbe289846f' target=_blank style='color:#2F92EE;'>#免疫反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28984, encryptionId=2bbe289846f, topicName=免疫反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305525, encodeId=706313055259f, content=<a href='/topic/show?id=270342e249d' target=_blank style='color:#2F92EE;'>#复苏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42724, encryptionId=270342e249d, topicName=复苏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481305, encodeId=ee881481305fd, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a597763398, createdName=ms3830150583600765, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1010352, encodeId=694d1010352b1, content=<a href='/topic/show?id=9b3996e6940' target=_blank style='color:#2F92EE;'>#锰#</a>与<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>,锰是一个极有潜力的治疗药物,便宜方便使用,建议大规模推广。不过从这篇文章来看,单纯MnO2或MnCl2效果似乎一般,还应该用一些<a href='/topic/show?id=28a6e73517e' target=_blank style='color:#2F92EE;'>#纳米#</a>技术进行改进,才可能取得更好的效果。另外,锰对<a href='/topic/show?id=a07f82814ec' target=_blank style='color:#2F92EE;'>#肿瘤免疫治疗#</a>方面,应该是一个重要的助手,也许将来有一天,锰,<a href='/topic/show?id=2d4c4140296' target=_blank style='color:#2F92EE;'>#地西他滨#</a>,甚至<a href='/topic/show?id=564f10439123' target=_blank style='color:#2F92EE;'>#沙度利胺#</a>这一类免疫调节剂联合或序贯使用,或根据免疫微环境特征,有针对性选择,可能更能诱导更强的免疫治疗效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=252, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=96769, encryptionId=9b3996e6940, topicName=锰), TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤), TopicDto(id=77351, encryptionId=28a6e73517e, topicName=纳米), TopicDto(id=82814, encryptionId=a07f82814ec, topicName=肿瘤免疫治疗), TopicDto(id=41402, encryptionId=2d4c4140296, topicName=地西他滨), TopicDto(id=104391, encryptionId=564f10439123, topicName=沙度利胺)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Aug 22 17:49:27 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280247, encodeId=803a128024eb3, content=<a href='/topic/show?id=2bbe289846f' target=_blank style='color:#2F92EE;'>#免疫反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28984, encryptionId=2bbe289846f, topicName=免疫反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305525, encodeId=706313055259f, content=<a href='/topic/show?id=270342e249d' target=_blank style='color:#2F92EE;'>#复苏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42724, encryptionId=270342e249d, topicName=复苏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481305, encodeId=ee881481305fd, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a597763398, createdName=ms3830150583600765, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1010352, encodeId=694d1010352b1, content=<a href='/topic/show?id=9b3996e6940' target=_blank style='color:#2F92EE;'>#锰#</a>与<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>,锰是一个极有潜力的治疗药物,便宜方便使用,建议大规模推广。不过从这篇文章来看,单纯MnO2或MnCl2效果似乎一般,还应该用一些<a href='/topic/show?id=28a6e73517e' target=_blank style='color:#2F92EE;'>#纳米#</a>技术进行改进,才可能取得更好的效果。另外,锰对<a href='/topic/show?id=a07f82814ec' target=_blank style='color:#2F92EE;'>#肿瘤免疫治疗#</a>方面,应该是一个重要的助手,也许将来有一天,锰,<a href='/topic/show?id=2d4c4140296' target=_blank style='color:#2F92EE;'>#地西他滨#</a>,甚至<a href='/topic/show?id=564f10439123' target=_blank style='color:#2F92EE;'>#沙度利胺#</a>这一类免疫调节剂联合或序贯使用,或根据免疫微环境特征,有针对性选择,可能更能诱导更强的免疫治疗效果, beContent=null, objectType=article, channel=null, level=null, likeNumber=252, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=96769, encryptionId=9b3996e6940, topicName=锰), TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤), TopicDto(id=77351, encryptionId=28a6e73517e, topicName=纳米), TopicDto(id=82814, encryptionId=a07f82814ec, topicName=肿瘤免疫治疗), TopicDto(id=41402, encryptionId=2d4c4140296, topicName=地西他滨), TopicDto(id=104391, encryptionId=564f10439123, topicName=沙度利胺)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Aug 22 17:49:27 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280247, encodeId=803a128024eb3, content=<a href='/topic/show?id=2bbe289846f' target=_blank style='color:#2F92EE;'>#免疫反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28984, encryptionId=2bbe289846f, topicName=免疫反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305525, encodeId=706313055259f, content=<a href='/topic/show?id=270342e249d' target=_blank style='color:#2F92EE;'>#复苏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42724, encryptionId=270342e249d, topicName=复苏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1d01326, createdName=lizhou0204, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481305, encodeId=ee881481305fd, content=<a href='/topic/show?id=c5534414ee6' target=_blank style='color:#2F92EE;'>#天然免疫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44147, encryptionId=c5534414ee6, topicName=天然免疫)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a597763398, createdName=ms3830150583600765, createdTime=Tue Aug 24 07:23:47 CST 2021, time=2021-08-24, status=1, ipAttribution=)]

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Eur J Epidemiol:每天吃5-6克洋葱,可以降低肝癌风险33%

结果表明,较高的视黄醇摄入量与肝癌风险增加相关,而较高的洋葱和锰摄入量与肝癌风险降低相关。

Biomaterials:中国海洋大学赵峡教授团队发现基于细胞焦亡和STING通路新型复合纳米粒抗癌有点“锰”

近期,中国海洋大学赵峡教授课题组结合基于透明质酸(HA)紫杉醇(PTX)前药与免疫系统的“传令兵”锰离子(Mn2+),设计了一种新型复合纳米粒(Mn-HSP)。

微量元素——锰与免疫健康

锰是一种人体14种必需的微量元素,在人体内的含量仅次于铁。锰具有提高免疫力、维持神经、改善造血系统、维持心脏和肌肉功能、预防心脑血管疾病等作用与功效。茶叶、小麦以及硬壳果实含锰较多。

NEJM:一例10 年进行性书写障碍和言语快速、含糊不清病例

一名 55 岁男性因有 10 年进行性书写障碍和言语快速、含糊不清的病史就诊于神经科诊所。

Radiology:锰与钆的对决--谁才是MR对比剂王座的主人?

本研究旨在比较锰磁共振(MR)对比剂Mn-PyC3A与钆MR对比剂Gd-DTPA的血管内强化效果,评价Mn-PyC3A的排泄、药物动力学参数和代谢,并将结果发表在Radiology上。

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