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Lancet Infect Dis:抗假单胞菌β-内酰胺治疗脓毒症:延长输注vs短期输注

2018-01-24 应颖秋 环球医学网

2018年1月,发表在《Lancet Infect Dis》上的一项系统评价和Meta分析,考察了延长vs短期静脉注射抗假单胞菌β-内酰胺在脓毒症患者中的有效性。

2018年1月,发表在《Lancet Infect Dis》上的一项系统评价和Meta分析,考察了延长vs短期静脉注射抗假单胞菌β-内酰胺在脓毒症患者中的有效性。

背景:对于延长β-内酰胺输注有效性的随机对照试验(RCT)、观察性研究和Meta分析的结果存在差异性。研究人员旨在确定脓毒症患者延长vs短期输注抗假单胞菌β-内酰胺的有效性。

方法:研究人员进行了一项系统评价和Meta分析,旨在比较延长vs短期静脉注射抗假单胞菌β-内酰胺在脓毒症患者中的有效性。两名作者独立地检索了截至2016年11月的Pubmed、Scopus和Cochrane图书馆上的临床试验,检索无日期或语言的限制。比较延长(连续或持续≥3h)vs短期(≤60分钟)抗假单胞菌β-内酰胺输注治疗脓毒症患者的死亡率或临床效果的任何RCT都符合入组标准。如果研究为非RCT,两组的抗生素不一样,未报道死亡率或临床效果,仅报道了药物代谢动力学或药效学结局,入组或随机分组的患者为10例或以下的研究,则被排除在本次研究之外。在预先设定的表格中提取数据,然后使用Mantel-Haenszel随机效应模型进行Meta分析。首要结局为任意时间点的全因死亡率。本Meta分析注册到PROSPERO数据库,注册号为CRD42016051678,根据PRISMA指南进行报道。

结果:共识别和筛选了2196篇文献, 其中22项研究(1876例患者)被纳入此次的Meta分析当中。根据建议评估、发展和评价的分级工具显示,死亡率的证据质量很高。研究了碳青霉烯类、青霉素类、头孢菌素类抗生素。纳入了具有不同年龄、急性生理学与慢性健康评价(APACHE)II评分、脓毒症严重程度和肾功能的患者。与短期输注相比,延长输注与较低的全因死亡率相关(RR,0.70;95% CI,0.56~0.87)。未观察到异质性(P=0.93;I2=0%)。漏斗图和Egger检验未发现发表偏倚的证据(P=0.44)。

结论:与短期输注相比,延长输注抗假单胞菌β-内酰胺治疗的脓毒症患者与显着性低的死亡率相关。需要进一步在不同年龄、脓毒症严重程度、肾功能不全和免疫活性程度的特异患者亚组中进行研究。

原始出处:
Vardakas KZ, Voulgaris GL, Maliaros A,et al.Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials.Lancet Infect Dis. 2018 Jan;18(1):108-120. doi: 10.1016/S1473-3099(17)30615-1. Epub 2017 Nov 5.
 

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    2018-03-01 howi
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    2018-01-25 海之蓝

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1829445, encodeId=0666182944540, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Mar 01 21:44:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800926, encodeId=f9581800926e8, content=<a href='/topic/show?id=1fdde3217e2' target=_blank style='color:#2F92EE;'>#短期输注#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73217, encryptionId=1fdde3217e2, topicName=短期输注)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Aug 17 20:44:00 CST 2018, time=2018-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012558, encodeId=fb67201255804, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Oct 11 07:44:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282037, encodeId=7c5c28203e35, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Thu Jan 25 23:13:16 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281912, encodeId=029e28191291, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jan 25 13:19:33 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281611, encodeId=8faa281611a6, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jan 24 14:15:40 CST 2018, time=2018-01-24, status=1, ipAttribution=)]
    2018-01-25 虈亣靌

    学习了.获益匪浅!感谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1829445, encodeId=0666182944540, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Thu Mar 01 21:44:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800926, encodeId=f9581800926e8, content=<a href='/topic/show?id=1fdde3217e2' target=_blank style='color:#2F92EE;'>#短期输注#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73217, encryptionId=1fdde3217e2, topicName=短期输注)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Fri Aug 17 20:44:00 CST 2018, time=2018-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012558, encodeId=fb67201255804, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Oct 11 07:44:00 CST 2018, time=2018-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282037, encodeId=7c5c28203e35, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Thu Jan 25 23:13:16 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281912, encodeId=029e28191291, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Jan 25 13:19:33 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281611, encodeId=8faa281611a6, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Jan 24 14:15:40 CST 2018, time=2018-01-24, status=1, ipAttribution=)]
    2018-01-24 神功盖世

    0

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