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Gut:地中海饮食干预可改变老年人的肠道微生物群

2020-10-23 MedSci原创 MedSci原创

衰老伴随着多种身体功能的退化和炎症,这些共同导致了体弱。身体虚弱情况随着肠道微生物群的变化而变化。地中海饮食与健康相关。

背景及目的:

衰老伴随着多种身体功能的退化和炎症,这些共同导致了体弱。先前已有研究表明,身体虚弱情况随着肠道微生物群的变化而变化。地中海饮食(MedDiet)与健康相关。因此,本研究旨在探究在NU-AGE项目中,一年的MedDiet干预是否可以改变肠道微生物群并改善健康状况。

方法:

研究人员为老年受试者量身定制的为期12个月的MedDiet干预措施。在干预措施实施前后,研究人员对五个欧洲国家(英国,法国,荷兰,意大利和波兰)的612名非体弱或体弱前受试者的肠道菌群进行了分析。

结果:

研究结果显示,坚持这项饮食计划可改变特定的微生物群。因坚持这项饮食计划而增多的微生物群能够使几种反映体质增强和认知功能改善的标志物升高,并降低包括C反应蛋白和白介素-17在内的炎症标志物。对微生物代谢产物的分析结果表明,饮食调节的微生物群变化与短链/支链脂肪酸产量的增加以及对甲酚、乙醇和二氧化碳的生成降低有关。微生物群落生态系统网络分析表明,对MedDiet干预反应积极的细菌类群占据着关键的相互作用位置,而与体弱相关的细菌类群则处于网络的外围。

结论:

本项研究结果支持改善习惯性饮食以调节肠道菌群的可行性,从而有可能促进人群更健康的衰老。

 

原始出处:

Tarini Shankar Ghosh, et al. Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. GUT. 2020.

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    2021-06-16 Roly

    学习

    0

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    2020-10-26 健康达人

    地中海饮食是热点,被认为是最健康的饮食,而中国传统饮食一般被认为多半是不健康的,这是事实吗?其实需要更多严谨的科学证据,而不是猜测!

    0

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    2020-10-25 wgx311
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    2020-10-25 上善若水任方圆

    地中海饮食研究的比较多了但和肠道菌群的研究一直较为缺乏,本篇研究很有指导意义

    0

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