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Crit Care:高氧血症与严重创伤后较低的死亡率相关

2020-10-13 MedSci原创 MedSci原创

在这项大型观察性研究中,创伤患者的早期高氧血症与降低的院内死亡率相关。

高氧血症与危重患者的死亡率增加有关,但对其在创伤患者中的作用尚未明确。近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,这项研究旨在评估严重创伤患者早期高氧血症与住院死亡率之间的关系。研究人员假设入院时动脉血氧分压(PaO2)≥150mmHg与住院死亡率增加相关。

研究人员使用法国多中心前瞻性创伤登记处发布的数据,纳入了2016年5月至2019年3月之间由急诊入院并入住I级创伤中心的创伤患者。早期高氧血症定义为住院时测得的PaO2高于150 mmHg。研究人员使用具有预定变量(性别、年龄、院前心率和收缩压、体温、血红蛋白和动脉血乳酸、血红蛋白和动脉血乳酸、机械通气、创伤性脑损伤(TBI)、初始格拉斯哥昏迷量表评分、损伤严重程度评分(ISS)、美国麻醉医师学会身体健康等级>I以及失血性休克)的倾向评分模型,比较常氧血症(150>PaO2≥60 mmHg)和高氧血症患者的院内死亡率。

该研究总共分析了5912例患者。受试者中位年龄为39 [26-55]岁,男性占78%。超过一半(53%)患者的ISS高于15,而32%的患者存在颅脑外伤。单因素分析表明,相比于常氧血症患者,高氧血症患者的住院死亡率升高(12% vs. 9%,p<0.0001)。然而,在倾向评分匹配后,研究人员发现高氧血症患者院内死亡率显著低于常氧血症患者(OR为0.59 [0.50–0.70],p<0.0001)。

在这项大型观察性研究中,创伤患者的早期高氧血症与降低的院内死亡率相关。

原始出处:

Josefine S. Baekgaard.et al.Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03274-x

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    2020-10-13 vip小康子

    不错呢,好好学习。

    0

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