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KIDNEY INT:体重指数增加是终末期肾病的危险因素!

2017-05-20 xing.T MedSci原创

因此,在一般人群中BMI本身是ESRD的一个危险因素,这种相关性是存在于那些没有预先存在的糖尿病、高血压、冠心病和卒中的个人。

体重指数(BMI)与终末期肾脏疾病(ESRD)之间的关系受到疾病相关并发症的混淆。此外,在低BMI范围个体中,这种相关性是存在争议的。近日,肾脏病领域权威杂志kidney international上发表了一篇研究文章,在这项研究中,研究人员在新加坡的中国健康研究中分析了这种相关性。

该研究是一个以人群为基础的前瞻性队列研究,招募了在新加坡的华人男性和女性,其年龄在1993年至1998年期间为45-74岁。自我报告体重、身高、生活方式因素、通常的饮食和病史,通过采访者管理问卷进行收集。ESRD病例的发生是通过与全国终末期肾病登记中心链接的记录来进行确定。研究人员采用计算Cox比例风险回归来调整潜在的危险因素。

平均随访15.5年后,研究人员确定了827例ESRD病例。与18.5-23kg/m2的正常BMI患者相比,BMI小于18、23-27.5和27.5kg/m2以上,发生ESRD的凤险比(95%可信区间)分别为0.54(0.37-0.79)、0.40(1.20-1.64)和2.13(1.74-2.59)。这种有显著趋势、线性、剂量依赖性的相关性只有在那些没有基础糖尿病高血压、冠心病和卒中的个体中才存在,但在这些合并症个体中不显著。

因此,在一般人群中BMI本身是ESRD的一个危险因素,这种相关性是存在于那些没有预先存在的糖尿病高血压、冠心病和卒中的个人。

原始出处:

Quan-Lan Jasmine Lew,et al. Increased body mass index is a risk factor for end-stage renal disease in the Chinese Singapore population.kidney-international.2017. http://www.kidney-international.org/article/S0085-2538(17)30214-4/fulltext

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    2017-05-22 gwc389
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content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 cqykthl

    控制体重,在高危人群中很重要

    0

  5. 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content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 QFXL123456

    临床中观察也是这样的,学习了

    0

  6. 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content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 135****7952平儿

    学习了。。。。。。。

    0

  7. 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likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sat May 20 14:19:57 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200435, encodeId=605520043565, content=学习了,不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhQkEvDREF6S2vZq3ZIpUYjdqicKVoAWaJSGoe8xNvS6o6QpmOlh2AQ7xuUpj8NiaDjJJgjbc7Xj3T6/0, createdBy=1c242047915, createdName=daiyaozu, createdTime=Sat May 20 13:18:12 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200432, encodeId=98f820043290, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sat May 20 13:13:53 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200430, encodeId=2bad2004305b, content=学习一下,不错的文章,学到了很多。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Sat May 20 13:07:42 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200428, encodeId=3ed62004280d, content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 daiyaozu

    学习了,不错

    0

  8. 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encodeId=98f820043290, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sat May 20 13:13:53 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200430, encodeId=2bad2004305b, content=学习一下,不错的文章,学到了很多。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Sat May 20 13:07:42 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200428, encodeId=3ed62004280d, content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 jiuling

    学习了,谢谢分享

    0

  9. 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encodeId=98f820043290, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=418d1603809, createdName=jiuling, createdTime=Sat May 20 13:13:53 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200430, encodeId=2bad2004305b, content=学习一下,不错的文章,学到了很多。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Sat May 20 13:07:42 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200428, encodeId=3ed62004280d, content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 Mr.Li先生

    学习一下,不错的文章,学到了很多。。。。

    0

  10. 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content=肥胖与很多疾病相关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat May 20 13:06:31 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 changjiu

    肥胖与很多疾病相关。

    0

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